id:"swepub:oai:DiVA.org:oru-63878"
Sökning: id:"swepub:oai:DiVA.org:oru-63878" > Short-term hypocalo...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04797naa a2200421 4500 | |
| 001 | oai:DiVA.org:oru-63878 | |
| 003 | SwePub | |
| 008 | 180105s1997 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:1933201 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-638782 URI |
| 024 | 7 | a https://doi.org/10.1016/S0899-9007(97)00335-32 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19332012 URI |
| 040 | a (SwePub)orud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Nygren, Jonasu Karolinska Institutet4 aut |
| 245 | 1 0 | a Short-term hypocaloric nutrition but not bed rest decrease insulin sensitivity and IGF-I bioavailability in healthy subjects :b the importance of glucagon |
| 264 | 1 | b Oxford University Press,c 1997 |
| 338 | a print2 rdacarrier | |
| 520 | a Hyperinsulinemic, normoglycemic clamps were performed before and after 24 h of either hypocaloric nutrition or bed rest in healthy subjects. Decreased insulin sensitivity and insulin-like growth factor-I (IGF-I) bioavailibility, as measured by the serum IGF-I/insulin-like growth factor binding protein-1 (IGFBP-1) ratio, was found after fasting, whereas no metabolic changes were found after bed rest. Glucagon seems to be a key regulator of IGFBP-1 after brief hypocaloric nutrition. Hypocaloric nutrition and immobilization may add to the catabolic response to surgery and other trauma. Presently, six healthy subjects were studied before and after a 24-h period of hypocaloric nutrition (200 kcal/24 h, fast) or immobilization (bed rest) using the hyperinsulinemic (0.8 mU · kg−1 · min−1), normoglycemic (4.5 mmol/L) clamp, indirect calorimetry, and circulating levels of substrates and hormones. After fast, body weight decreased (P < 0.05), and nitrogen balance was negative (−10 ± 1 g urea nitrogen/24 h). Basal levels of free fatty acids, glucagon, and IGFBP-1 increased (P < 0.05), whereas c-peptide levels and the IGF-I/IGFBP-1 ratio decreased (P < 0.05). However, no change was found in basal levels of IGF-I or substrate oxidation. Furthermore, changes (%) in basal levels of glucagon after fast correlated to IGFBP-1 (r = 1.0, P < 0.05), whereas the suppressibility of IGFBP-1 by insulin was maintained at normal levels. During clamps, glucose infusion rates (GIR) decreased after fast (−43 ± 13%, mean ± SEM, P < 0.001). Although not significant, clamp levels of fat oxidation tended to increase and glucose oxidation tended to decrease. Levels of IGFBP-1 during clamps were higher as compared with the control clamp (P < 0.05). No adverse metabolic changes were seen after bed rest, and no change in GIR during clamps were seen as compared with the control measurement (0 ± 14%). After brief hypocaloric nutrition, insulin sensitivity is reduced, whereas IGF-I bioavailibility is reduced by an increase in levels of IGFBP-1. Glucagon seems to contribute to the increase in IGFBP-1 during these conditions. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng |
| 700 | 1 | a Thorell, Andersu Department of Surgery, Karolinska Hospital, Stockholm, Sweden4 aut |
| 700 | 1 | a Brismar, Kerstinu Karolinska Institutet4 aut |
| 700 | 1 | a Karpe, Fredriku Department of Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden4 aut |
| 700 | 1 | a Ljungqvist, Olle,d 1954-u Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Surgery, Karolinska Hospital, Stockholm, Sweden4 aut0 (Swepub:oru)olt |
| 710 | 2 | a Karolinska Institutetb Department of Surgery, Karolinska Hospital, Stockholm, Sweden4 org |
| 773 | 0 | t Journal of Nutritiond : Oxford University Pressg 13:11-12, s. 945-951q 13:11-12<945-951x 0022-3166x 1541-6100 |
| 773 | 0 | t Nutrition (Burbank, Los Angeles County, Calif.)d : Oxford University Pressg 13:11-12, s. 945-951q 13:11-12<945-951x 0899-9007 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-63878 |
| 856 | 4 8 | u https://doi.org/10.1016/S0899-9007(97)00335-3 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1933201 |
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