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Antimicrobials : Strategies for targeting obesity and metabolic health?

Murphy, Eileen F. (author)
Alimentary Health Ltd., Cork, Ireland
Clarke, Siobhan F. (author)
Teagasc Moorepark Food Research Centre, Fermoy, Ireland; Department of Microbiology, University College Cork, Cork, Ireland
Marques, Tatiana M., 1980- (author)
Teagasc Moorepark Food Research Centre, Fermoy, Ireland; Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
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Hill, Colin (author)
Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Department of Microbiology, University College Cork, Cork, Ireland
Stanton, Catherine (author)
Teagasc Moorepark Food Research Centre, Fermoy, Ireland; Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
Ross, R. Paul (author)
Teagasc Moorepark Food Research Centre, Fermoy, Ireland; Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
O'Doherty, Robert M. (author)
Department of Medicine, Division of Endocrinology and Metabolism and Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh PA, USA
Shanahan, Fergus (author)
Teagasc Moorepark Food Research Centre, Fermoy, Ireland; Department of Medicine, University College Cork, Cork, Ireland
Cotter, Paul D. (author)
Teagasc Moorepark Food Research Centre, Fermoy, Ireland; Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
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Alimentary Health Ltd, Cork, Ireland Teagasc Moorepark Food Research Centre, Fermoy, Ireland; Department of Microbiology, University College Cork, Cork, Ireland (creator_code:org_t)
2014-10-27
2013
English.
In: Gut microbes. - : Landes Bioscience. - 1949-0976 .- 1949-0984. ; 4:1, s. 48-53
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Obesity is associated with a number of serious health consequences, including type 2 diabetes, cardiovascular disease and a variety of cancers among others and has been repeatedly shown to be associated with a higher risk of mortality. The relatively recent discovery that the composition and metabolic activity of the gut microbiota may affect the risk of developing obesity and related disorders has led to an explosion of interest in this distinct research field. A corollary of these findings would suggest that modulation of gut microbial populations can have beneficial effects with respect to controlling obesity. In this addendum, we summarize our recent data, showing that therapeutic manipulation of the microbiota using different antimicrobial strategies may be a useful approach for the management of obesity and metabolic conditions. In addition, we will explore some of the mechanisms that may contribute to microbiota-induced susceptibility to obesity and metabolic diseases.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)

Keyword

Antimicrobials
firmicutes
gut microbiota
metabolic disease
obesity

Publication and Content Type

ref (subject category)
art (subject category)

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