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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03990naa a2200433 4500 | |
| 001 | oai:DiVA.org:oru-70388 | |
| 003 | SwePub | |
| 008 | 181130s2018 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:139719648 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-703882 URI |
| 024 | 7 | a https://doi.org/10.3390/ijerph151123712 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1397196482 URI |
| 040 | a (SwePub)orud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a for2 swepub-publicationtype |
| 100 | 1 | a Gunnarsson, Lars-Gunnar,d 1948-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Occupational and Environmental Medicine4 aut0 (Swepub:oru)lgn |
| 245 | 1 0 | a Amyotrophic Lateral Sclerosis and Occupational Exposures :b A Systematic Literature Review and Meta-Analyses |
| 264 | c 2018-10-26 | |
| 264 | 1 | b MDPI AG,c 2018 |
| 338 | a print2 rdacarrier | |
| 500 | a Funding Agency:Department of Occupational and Environmental Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden | |
| 520 | a Objectives: We conducted a systematic literature review to identify studies fulfilling good scientific epidemiological standards for use in meta-analyses of occupational risk factors for amyotrophic lateral sclerosis (ALS). Methods: We identified 79 original publications on associations between work and ALS. The MOOSE (Meta-analysis Of Observational Studies in Epidemiology) and GRADE (Grading of Recommendations, Assessment, Development and Evaluations) guidelines were used to ensure high scientific quality, and reliable protocols were applied to classify the articles. Thirty-seven articles fulfilled good scientific standards, while 42 were methodologically deficient and thus were excluded from our meta-analyses. Results: The weighted relative risks for the various occupational exposures were respectively; 1.29 (95% confidence interval (CI): 0.97⁻1.72; six articles) for heavy physical work, 3.98 (95% CI: 2.04⁻7.77; three articles) for professional sports, 1.45 (95% CI: 1.07⁻1.96; six articles) for metals, 1.19 (95% CI: 1.07⁻1.33; 10 articles) for chemicals, 1.18 (95% CI: 1.07⁻1.31; 16 articles) for electromagnetic fields or working with electricity, and 1.18 (95% CI: 1.05⁻1.34; four articles) for working as a nurse or physician. Conclusions: Meta-analyses based only on epidemiologic publications of good scientific quality show that the risk of ALS is statistically significantly elevated for occupational exposures to excessive physical work, chemicals (especially pesticides), metals (especially lead), and possibly also to electromagnetic fields and health care work. These results are not explained by publication bias. | |
| 650 | 7 | a NATURVETENSKAPx Matematikx Sannolikhetsteori och statistik0 (SwePub)101062 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Mathematicsx Probability Theory and Statistics0 (SwePub)101062 hsv//eng |
| 653 | a chemicals | |
| 653 | a electromagnetic fields | |
| 653 | a epidemiology | |
| 653 | a metals | |
| 653 | a physical activity | |
| 700 | 1 | a Bodin, Lennart,d 1941-u Karolinska Institutet,Örebro universitet,Handelshögskolan vid Örebro Universitet,Department of Statistics, Örebro University, Örebro, Sweden; Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden4 aut0 (Swepub:oru)lbn |
| 710 | 2 | a Örebro universitetb Institutionen för medicinska vetenskaper4 org |
| 773 | 0 | t International Journal of Environmental Research and Public Healthd : MDPI AGg 15:11q 15:11x 1661-7827x 1660-4601 |
| 856 | 4 | u https://doi.org/10.3390/ijerph15112371y Fulltext |
| 856 | 4 | u https://www.mdpi.com/1660-4601/15/11/2371/pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-70388 |
| 856 | 4 8 | u https://doi.org/10.3390/ijerph15112371 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:139719648 |
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