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Effects of omega-3 ...
Effects of omega-3 fatty acids on inflammatory markers in cerebrospinal fluid and plasma in Alzheimer's disease : the OmegAD study
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- Freund-Levi, Yvonne, 1956- (author)
- Divisions of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Huddinge, Stockholm
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- Hjorth, Erik (author)
- Karolinska Institutet
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- Lindberg, Catharina (author)
- Divisions of Neurodegeneration, Department of Neurobiology, Care Sciences and Society (NVS), Huddinge, Stockholm
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- Cederholm, Tommy (author)
- Karolinska Institutet,Uppsala universitet,Klinisk nutrition och metabolism
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- Faxen-Irving, Gerd (author)
- Karolinska Institutet
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- Vedin, Inger (author)
- Karolinska Institutet
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- Palmblad, Jan (author)
- Karolinska Institutet
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- Wahlund, Lars-Olof (author)
- Karolinska Institutet
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- Schultzberg, Marianne (author)
- Karolinska Institutet
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- Basun, Hans (author)
- Uppsala universitet,Geriatrik
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- Eriksdotter Jönhagen, Maria (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2009-05-12
- 2009
- English.
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In: Dementia and Geriatric Cognitive Disorders. - : S. Karger. - 1420-8008 .- 1421-9824. ; 27:5, s. 481-490
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- BACKGROUND: omega-3 fatty acids (omega-3 FAs) found in dietary fish or fish oils are anti-inflammatory agents that may influence Alzheimer's disease (AD).OBJECTIVE: To study the effects of dietary omega-3 FA supplementation on inflammatory markers in cerebrospinal fluid (CSF) and plasma from patients with mild to moderate AD.METHODS: Thirty-five patients (70.3 +/- 8.2 years) were randomized to a daily intake of 2.3 g omega-3 FAs or placebo for 6 months. The inflammatory markers interleukin (IL)-6, tumour necrosis factor-alpha and soluble interleukin-1 receptor type II (sIL-1RII) were analysed in CSF and plasma at baseline and at 6 months. The AD markers tau-protein, hyperphosphorylated tau-protein and beta-amyloid (Abeta(1-42)) were assessed in CSF. High-sensitivity C-reactive protein was assessed in plasma. A possible relation to the APOE genotype was investigated.RESULTS: There was no significant treatment effect of omega-3 FAs on inflammatory and AD biomarkers in CSF or on inflammatory markers in plasma, nor was there any relation with APOE. A significant correlation was observed at baseline between sIL-1RII and Abeta(1-42) levels in CSF.CONCLUSIONS: Treatment of AD patients with omega-3 FAs for 6 months did not influence inflammatory or biomarkers in CSF or plasma. The correlation between sIL-1RII and Abeta(1-42) may reflect the reciprocal interactions between IL-1 and Abeta peptides.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Alzheimer's disease
- Inflammation
- Cerebrospinal fluid
- omega-3 fatty acids
- Cytokines
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Freund-Levi, Yvo ...
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Hjorth, Erik
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Lindberg, Cathar ...
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Cederholm, Tommy
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Faxen-Irving, Ge ...
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Vedin, Inger
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show more...
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Palmblad, Jan
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Wahlund, Lars-Ol ...
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Schultzberg, Mar ...
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Basun, Hans
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Eriksdotter Jönh ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Dementia and Ger ...
- By the university
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Örebro University
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Uppsala University
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Karolinska Institutet