id:"swepub:oai:DiVA.org:oru-76406"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04037naa a2200445 4500 | |
| 001 | oai:DiVA.org:oru-76406 | |
| 003 | SwePub | |
| 008 | 190913s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-764062 URI |
| 040 | a (SwePub)oru | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a kon2 swepub-publicationtype |
| 100 | 1 | a Tran, Pham Tue Hung,d 1991-u Örebro universitet,Institutionen för medicinska vetenskaper,Molecular Flavirus group4 aut0 (Swepub:oru)hgtn |
| 245 | 1 0 | a Identification and characterization of host proteins inducing the endoplasmic reticulum invagination during Flavivirus infection |
| 264 | 1 | c 2019 |
| 338 | a electronic2 rdacarrier | |
| 520 | a When Flaviviruses infect host cells, they can induce invagination of endoplasmic reticulum (ER) membrane to form vesicle-like compartments. These unique structures are hypothetical to facilitate the viral replication by reducing diffusion of virus replication machinery and viral RNA, providing a scaffold to anchor the replication complex, and protecting viral RNA from host cell intrinsic surveillance. The rearrangements of ER membrane to form these replication compartments (RCs) require modifications in its lipid constituents or binding of proteins to the membrane. Flaviviruses, indeed, use their proteins to generate RCs. It has been implicated that both KUNV and DENV viral NS1, NS2A, NS4A, NS4B proteins could induce membrane remodelings. However, it is recondite whether host proteins can also participate in the formation and maintenance of RCs.In this project, we aimed to identify and characterize of host proteins inducing RC generation during Flavivirus infections. We used A549 as a cell model, and mosquito-borne Zika and Kunjin virus, and tick-borne Langat virus as virus models. After virus infections, ER membranes were harvested using ultracentrifuge with a sucrose gradient. Proteins from these ERs were identified using mass spectrometry. We compared the differences between the ER proteomes of infected cells and non-infected cells to identify host candidate proteins that can cause the RC formation. We are attempting to enrich the RC-containing fractions and identifying proteins here, which narrows the list of true candidate proteins. The candidate proteins then will be characterized by using molecular techniques such as gene knock down, overexpression, and microscopy techniques. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng |
| 653 | a Replication complex | |
| 653 | a Kunjin | |
| 653 | a Langat | |
| 653 | a Zika | |
| 653 | a Molekylär cellbiologi | |
| 653 | a Molecular Cellbiology | |
| 653 | a Biomedicin | |
| 653 | a Biomedicine | |
| 653 | a Infektionssjukdomar | |
| 653 | a Infectious Diseases | |
| 700 | 1 | a Asghar, Naveed,d 1983-u Örebro universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:oru)nar |
| 700 | 1 | a Karlsson, Rogeru Department ofClinical Microbiology, Sahlgrenska University Hospital, Gothenburg, Sweden; NanoxisConsulting AB, Gothenburg, Sweden4 aut |
| 700 | 1 | a Karlsson, Andersu Department ofClinical Microbiology, Sahlgrenska University Hospital, Gothenburg, Sweden; NanoxisConsulting AB, Gothenburg, Sweden4 aut |
| 700 | 1 | a Johansson, Magnus,d 1969-u Örebro universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:oru)msja |
| 700 | 1 | a Melik, Wessam,d 1973-u Örebro universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:oru)wmk |
| 710 | 2 | a Örebro universitetb Institutionen för medicinska vetenskaper4 org |
| 773 | 0 | t Positive-Strand RNA Viusesg , s. 280-280q <280-280 |
| 856 | 4 | u https://oru.diva-portal.org/smash/get/diva2:1351296/FULLTEXT03.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-76406 |
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