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Perinatal and antib...
Perinatal and antibiotic exposures and the risk of developing childhood-onset inflammatory bowel disease : A nested case-control study based on a population-based birth cohort
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- Canova, C. (author)
- Unit of Biostatistics, Epidemiology and Public Health, Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padua, Padua, Italy
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- Ludvigsson, Jonas F., 1969- (author)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro University, Örebro, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, United Kingdom; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, United States
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- Di Domenicantonio, R. (author)
- Department of Epidemiology, Lazio Regional Health Service, ASL Rome, Italy
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- Zanier, L. (author)
- Epidemiological Service, Health Directorate, Udine, Italy
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- Amidei, C. B. (author)
- Unit of Biostatistics, Epidemiology and Public Health, Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padua, Padua, Italy
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- Zingone, F. (author)
- Department of Surgery, Oncology and Gastroenterology, Gastroenterology Section, University Hospital of Padua, Padua, Italy
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(creator_code:org_t)
- 2020-04-02
- 2020
- English.
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In: International Journal of Environmental Research and Public Health. - : MDPI. - 1661-7827 .- 1660-4601. ; 17:7
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Abstract
Subject headings
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- The role of early-life environmental exposures on Inflammatory Bowel Disease (IBD) onset remains unclear. We aimed to quantify the impact of perinatal conditions and antibiotic use in the first 6 and 12 months of life, on the risk of childhood-onset IBD, in a birth cohort of the region Friuli-Venezia Giulia (Italy). A nested case-control design on a longitudinal cohort of 213,515 newborns was adopted. Conditional binomial regression models were used to estimate Odds Ratios (OR) with 95% confidence intervals (CI) for all analyzed risk factors. We identified 164 individuals with IBD onset before the age of 18 years and 1640 controls. None of the considered perinatal conditions were associated with IBD. Analyses on antibiotic exposure were based on 70 cases and 700 controls. Risks were significantly higher for children with ≥4 antibiotic prescriptions in the first 6 and 12 months of life (OR = 6.34; 95%CI 1.68–24.02 and OR = 2.91; 95%CI 1.31–6.45, respectively). This association was present only among patients with Crohn’s disease and those with earlier IBD onset. We found that perinatal characteristics were not associated to IBD, while the frequent use of antibiotics during the first year of life was associated to an increased risk of developing subsequent childhood-onset IBD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- Birth cohort study
- Crohn disease
- Epidemiology
- Pediatric IBD
- Perinatal and postnatal exposure
- Pharmacoepidemiology
- Real-world data
- Record linkage
- Ulcerative colitis
- VEO-IBD
- antibiotic agent
- antibiotics
- child health
- digestive system disorder
- disease incidence
- drug prescribing
- health risk
- risk assessment
- risk factor
- adult
- Article
- birth
- case control study
- child
- childhood
- cohort analysis
- confidence interval
- controlled study
- female
- human
- inflammatory bowel disease
- Italy
- longitudinal study
- major clinical study
- male
- newborn
- odds ratio
- onset age
- perinatal period
- population research
- prescription
- retrospective study
- Friuli-Venezia Giulia
Publication and Content Type
- ref (subject category)
- art (subject category)
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