id:"swepub:oai:DiVA.org:oru-82816"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04343naa a2200397 4500 | |
| 001 | oai:DiVA.org:oru-82816 | |
| 003 | SwePub | |
| 008 | 200609s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-828162 URI |
| 024 | 7 | a https://doi.org/10.1016/j.ijbiomac.2019.01.0482 DOI |
| 040 | a (SwePub)oru | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Castro Alves, Victor,d 1986-u Department of Food Science and Experimental Nutrition, University of São Paulo, São Paulo, Brazil; Food Research Center (FoRC), CEPID-FAPESP, São Paulo, Brazil4 aut0 (Swepub:oru)vcs |
| 245 | 1 0 | a Polysaccharides from chayote enhance lipid efflux and regulate NLRP3 inflammasome priming in macrophage-like THP-1 cells exposed to cholesterol crystals |
| 264 | 1 | b Elsevier,c 2019 |
| 338 | a print2 rdacarrier | |
| 500 | a Funding Agency:Sao Paulo Research Foundation (FAPESP), Grant Number: 2013/07914-8Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES), Grant Number: 001FAPESP, Grant Number: 2016/05083-0National Council for Scientific and Technological Development (CNN), Grant Number: 310889/2014-6 | |
| 520 | a The contribution of dietary fiber to decrease the risk of atherosclerosis may occur through other mechanisms besides the increased excretion of cholesterol. Although macrophages are crucial for lipid clearance, the excessive uptake of cholesterol crystals (CC) by these cells induce NLRP3 inflammasome and foam cell formation. Thus, we investigated whether the water-soluble DF from chayote (WSP) regulate CC-pretreated macrophage-like THP-1 cells. Linkage analysis indicated that WSP is composed mainly of pectic homogalacturonan and highly branched type I rhamnogalacturonan as well as hemicellulosic material including glucomannan, xyloglucan, and glucurono(arabino)xylan. WSP reduced interleukin (IL)-1β and chemokine release in CC-pretreated macrophages. Notably, WSP also reduced lipid accumulation in cells previously exposed to CC. Furthermore, WSP upregulated liver X receptor alpha expression, which may account for increased lipid efflux, and reduced matrix metallopeptidase 9 expression. WSP also reduced active caspase-1 protein levels, and downregulated NLRP3 and IL-1β gene expression in CC-pretreated cells, suggesting that this polysaccharide fraction regulates the priming signals required for NLRP3 inflammasome activation. Thus, WSP regulate lipid efflux and suppress inflammasome priming in macrophages, suggesting that the health benefits of this dietary fiber could go beyond its physical properties on the gastrointestinal tract. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng |
| 653 | a Atherosclerosis | |
| 653 | a Cholesterol crystals | |
| 653 | a Dietary fiber | |
| 653 | a Inflammasome | |
| 653 | a Liver X receptor | |
| 653 | a Sechium edule | |
| 700 | 1 | a Misuzu Shiga, Tâniau Department of Food Science and Experimental Nutrition, University of São Paulo, São Paulo, Brazil; Food Research Center (FoRC), CEPID-FAPESP, São Paulo, Brazil4 aut |
| 700 | 1 | a Oliveira do Nascimento, João R.u Department of Food Science and Experimental Nutrition, University of São Paulo, São Paulo, Brazil; Food Research Center (FoRC), CEPID-FAPESP, São Paulo, Brazil; Food and Nutrition Research Center (NAPAN), University of São Paulo, São Paulo, Brazil4 aut |
| 710 | 2 | a Department of Food Science and Experimental Nutrition, University of São Paulo, São Paulo, Brazil; Food Research Center (FoRC), CEPID-FAPESP, São Paulo, Brazilb Department of Food Science and Experimental Nutrition, University of São Paulo, São Paulo, Brazil; Food Research Center (FoRC), CEPID-FAPESP, São Paulo, Brazil; Food and Nutrition Research Center (NAPAN), University of São Paulo, São Paulo, Brazil4 org |
| 773 | 0 | t International Journal of Biological Macromoleculesd : Elsevierg 127, s. 502-510q 127<502-510x 0141-8130x 1879-0003 |
| 856 | 4 | u https://doi.org/10.1016/j.ijbiomac.2019.01.048 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-82816 |
| 856 | 4 8 | u https://doi.org/10.1016/j.ijbiomac.2019.01.048 |
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