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α-and β-D-Glucans f...
α-and β-D-Glucans from the edible mushroom Pleurotus albidus differentially regulate lipid-induced inflammation and foam cell formation in human macrophage-like THP-1 cells
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- Castro Alves, Victor, 1986- (author)
- Department of Food Science and Experimental Nutrition, University of São Paulo, São Paulo, Brazil; Food Research Center (FoRC), CEPID-FAPESP, São Paulo, Brazil
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- Oliveira do Nascimento, João R. (author)
- Department of Food Science and Experimental Nutrition, University of São Paulo, São Paulo, Brazil; Food Research Center (FoRC), CEPID-FAPESP, São Paulo, Brazil; Food and Nutrition Research Center (NAPAN), University of São Paulo, São Paulo, Brazil
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(creator_code:org_t)
- Elsevier, 2018
- 2018
- English.
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In: International Journal of Biological Macromolecules. - : Elsevier. - 0141-8130 .- 1879-0003. ; 111, s. 1222-1228
- Related links:
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Abstract
Subject headings
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- Macrophages play an essential role in lipid metabolism; however, the excessive uptake of modified lipids andcholesterol crystals (CC) leads to the formation of pro-inflammatory lipid-laden macrophages called foam cells.Since theα-1,6- andβ-1,3-D-glucans from the basidiome and the mycelium of the edible mushroomPleurotusalbidushave previously been shown to regulate macrophage function, these glucans were tested in macro-phage-like THP-1 cells previously exposed to acetylated low-density lipoproteins (acLDL) or CC. The glucansinhibited lipid-induced inflammation, but only theβ-1,3-D-glucan regulated both the NLRP3 inflammasome ac-tivation and the expression of genes involved on lipid efflux in acLDL- or CC-pretreated cells, thereby reducingfoam cell formation. In contrast, the twoα-1,6-glucans tested inhibited foam cell formation only in acLDL-pretreated cells and had no effect on the expression of the peroxisome proliferator-activated receptor gammaand liver X receptor alpha genes, suggesting that these glucans regulate lipid influx rather than lipid efflux.Thus,α-andβ-D-glucans differentially regulate lipid-induced inflammation and foam cell formation in macro-phage-like cells. Furthermore, results emphasize thatP. albidushas potential to be used as a functional food oras a source for the extraction of biologically-active glucans.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Keyword
- Cholesterol crystals
- NLRP3 inflammasome
- Polysaccharide
Publication and Content Type
- ref (subject category)
- art (subject category)
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