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Liquid chromatography-ion mobility-high resolution mass spectrometry for analysis of pollutants in indoor dust : Identification and predictive capabilities
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- Mullin, L. (författare)
- Waters Corporation, Milford MA, United States
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- Jobst, K. (författare)
- Memorial University of Newfoundland, St John's NL, Canada
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- DiLorenzo, R. A. (författare)
- Department of Physiology and Experimental Medicine, The Hospital for Sick Children, Mouse Imaging Centre, Toronto, ON, Canada
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- Elsevier, 2020
- 2020
- Engelska.
- Ingår i: Analytica Chimica Acta. - : Elsevier. - 0003-2670 .- 1873-4324. ; 1125, s. 29-40
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Dust analysis provides a means to assess the degree of exposure of humans in an indoor environment to various contaminant classes such as flame retardants, pesticides and others. There is increasing interest in non-targeted acquisitions using high resolution mass spectrometry (HRMS) to better capture the contaminant profile. However, these studies are confronted with the challenge of assessing confidence in proposed identifications, particularly when authentic standards are not available. Here, we demonstrate the analysis of dust extracts representing various indoor environments (industrial e-waste processing and domestic) for high-abundance environmental contaminants using a data-independent LC-HRMS approach, incorporating ion mobility spectrometry (IMS) to provide additional characterization capability for the complex samples. Twenty-nine xenobiotic compound identifications were made based on both targeted and non-targeted processing approaches using accurate mass precursor and product ion measurement combined with an ion mobility derived collision-cross section (TWCCSN2) determination. Characterization of the repeatability of TWCCSN2 value measurements and their average relative error to compared authentic standards of 0.38% were consistent with various published studies and represent a robust measurement property. TWCCSN2 values were particularly useful in cases where confirmation after the initial dust analysis was performed using a different chromatographic method, due to the gas-phase measurement being unaffected by such changes. Observed compound TWCCSN2 values were then compared to predicted CCSN2 values obtained using two different machine-learning based predictive techniques. Results from one of the predictive programs indicates a promising avenue for use of these models for supporting compound identification in non-targeted analyses.
Ämnesord
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
Nyckelord
- Collisioncross section
- Data independent acquisition
- High resolution mass spectrometry
- Liquid chromatography
- Non-targeted screening
- Travelling-wave ion mobility
- Chromatographic analysis
- Dust
- Electronic Waste
- Flame retardants
- Gas chromatography
- Ions
- Mass spectrometry
- Phase measurement
- Average relative error
- Chromatographic methods
- Collision cross sections
- Environmental contaminant
- Gas-phase measurement
- Ion mobility spectrometry
- Predictive capabilities
- Ion chromatography
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- Mullin, L.
- Jobst, K.
- DiLorenzo, R. A.
- Plumb, R.
- Reiner, E. J.
- Yeung, Leo W. Y. ...
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