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Serum Metabolites i...
Serum Metabolites in Hand-Arm Vibration Exposed Workers
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- Vihlborg, Per, 1978- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Occupational and Environmental Medicine
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- Graff, Pål (författare)
- National Institute of Occupational Health, Oslo, Norway
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- Hagenbjörk, Annika (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Hadrévi, Jenny, 1977- (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Bryngelsson, Ing-Liss (författare)
- Department of Occupational and Environmental Medicine, Faculty ofMedicine and Health, Örebro University, Örebro, Sweden
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- Eriksson, Kåre (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 2020
- 2020
- Engelska.
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Ingår i: Journal of Occupational and Environmental Medicine. - : Lippincott Williams & Wilkins. - 1076-2752 .- 1536-5948. ; 62:7, s. 460-465
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Objective: To investigate whether low molecular organic biomarkers could be identified in blood samples from vibration exposed workers using a metabolomics.Methods: The study population consisted of 38 metalworkers. All participants underwent a standardized medical examination. Blood samples were collected before and after work shift and analyzed with gas chromatography time-of-flight mass spectrometry. Multivariate modeling (orthogonal partial least-squares analysis with discriminant analysis [OPLS-DA]) were used to verify differences in metabolic profiles.Results: Twenty-two study participants reported vascular symptoms judged as vibration-related. The metabolic profile from participants with vibration-induced white fingers (VWF) was distinctly separated from participants without VWF, both before and after vibration exposure.Conclusion: Metabolites that differed between the groups were identified both before and after exposure. Some of these metabolites might be indicators of health effects from exposure to vibrations. This is the first time that a metabolomic approach has been used in workers exposed to vibrations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Biomarkers
- Hand-arm vibration
- Metabolites
- Vibration-induced white fingers
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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