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β-lactamase-mediate...
β-lactamase-mediated resistance in MDR-Pseudomonas aeruginosa from Qatar
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- Sid Ahmed, Mazen, 1970- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Division of Microbiology, Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar,The Life Science Centre - Biology
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- Khan, Faisal Ahmad, 1986- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,The Life Science Centre - Biology
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- Sultan, Ali A. (författare)
- Department of Microbiology and Immunology, Weill Cornell Medicine-Qatar, Doha, Qatar
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- Söderquist, Bo, 1955- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Ibrahim, Emad Bashir (författare)
- Division of Microbiology, Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar; Department of Microbiology and Immunology, Weill Cornell Medicine-Qatar, Doha, Qatar
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- Jass, Jana, 1963- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,The Life Science Centre - Biology
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- Omrani, Ali S. (författare)
- Division of Infectious Diseases, Department of Medicine, Hamad Medical Corporation, Doha, Qatar; Communicable Diseases Center, Hamad Medical Corporation, Doha, Qatar
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(creator_code:org_t)
- 2020-11-01
- 2020
- Engelska.
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Ingår i: Antimicrobial Resistance and Infection Control. - : BioMed Central (BMC). - 2047-2994. ; 9:1
- Relaterad länk:
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https://doi.org/10.1...
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https://aricjournal....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: The distribution of β-lactam resistance genes in P. aeruginosa is often closely related to the distribution of certain high-risk international clones. We used whole-genome sequencing (WGS) to identify the predominant sequence types (ST) and β-lactamase genes in clinical isolates of multidrug-resistant (MDR)-P. aeruginosa from Qatar METHODS: Microbiological identification and susceptibility tests were performed by automated BD Phoenix™ system and manual Liofilchem MIC Test Strips.RESULTS: Among 75 MDR-P. aeruginosa isolates; the largest proportions of susceptibility were to ceftazidime-avibactam (n = 36, 48%), followed by ceftolozane-tazobactam (30, 40%), ceftazidime (n = 21, 28%) and aztreonam (n = 16, 21.3%). All isolates possessed Class C and/or Class D β-lactamases (n = 72, 96% each), while metallo-β-lactamases were detected in 20 (26.7%) isolates. Eight (40%) metallo-β-lactamase producers were susceptible to aztreonam and did not produce any concomitant extended-spectrum β-lactamases. High risk ST235 (n = 16, 21.3%), ST357 (n = 8, 10.7%), ST389 and ST1284 (6, 8% each) were most frequent. Nearly all ST235 isolates (15/16; 93.8%) were resistant to all tested β-lactams.CONCLUSION: MDR-P. aeruginosa isolates from Qatar are highly resistant to antipseudomonal β-lactams. High-risk STs are predominant in Qatar and their associated MDR phenotypes are a cause for considerable concern.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Beta-lactamases
- MDR
- P. aeruginosa
- ST235
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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