Risk of Skin Disorders in Patients with Celiac Disease: A Population-Based Cohort Study

Risk of Skin Disorders in Patients with Celiac Disease : A Population-Based Cohort Study

Lebwohl, Benjamin (author): Celiac Disease Center, Department of Medicine, Columbia University Medical Center, New York NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York NY, USA

Lebwohl, Mark G. (author): Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

Green, Peter Hr (author): Celiac Disease Center, Department of Medicine, Columbia University Medical Center, New York NY, USA

Ludvigsson, Jonas F., 1969- (author): Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Celiac Disease Center, Department of Medicine, Columbia University Medical Center, New York NY, USA; Department Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden

(creator_code:org_t)

Elsevier, 2021
2021
English.
In: The Journal of American Academy of Dermatology. - : Elsevier. - 0190-9622 .- 1097-6787. ; 85:6, s. 1456-1464

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; http://kipublication...; show less...

Abstract Subject headings

BACKGROUND AND AIMS: Although dermatitis herpetiformis is closely associated with celiac disease (CD), data on the relationship between CD and other dermatologic disorders have been mixed. We aimed to quantify the risk of skin disorders in patients after CD diagnosis in a population-based setting.METHODS: Using data from all 28 pathology departments in Sweden 1969-2016, we identified patients with CD. Each patient was matched by age, sex, calendar year, and geographic region to up to 5 population controls. We calculated the risk of any skin disease and specific skin diseases using Cox proportional hazards.RESULTS: We identified 43,300 patients with CD and 198,532 matched controls. After a median follow-up time of 11.4 years, the incidences of skin disease in CD patients and controls were 22.6 and 14.8 per 1000 person-years respectively (HR=1.55; 95%CI 1.51-1.58). Increased risks were present for eczema (HR=1.67; 95%CI 1.56-1.79), psoriasis (HR=1.55; 95%CI 1.43-1.68), urticaria (HR=1.52; 95% CI 1.42-1.64), vitiligo (HR=1.90; 95%CI 1.52-2.39), acne (HR=1.39; 95%CI 1.29-1.50), and alopecia areata (HR=1.78; 95%CI 1.43-2.20).CONCLUSIONS: Compared to the general population, patients with CD are at increased risk of multiple common skin disorders, a risk that persists in the long-term.

By the author/editor: Lebwohl, Benjami ...; Söderling, Jonas; Roelstraete, Bjo ...; Lebwohl, Mark G.; Green, Peter Hr; Ludvigsson, Jona ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dermatology and ...

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