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Loss of a co-twin a...
Loss of a co-twin at birth and subsequent risk of psychiatric disorders
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- Song, Huan (author)
- West China Biomedical Big Data Center, West China Hospital, Sichuan University, Sichuan, China; Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- Fang, Fang (author)
- Karolinska Institutet
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- Larsson, Henrik, 1975- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- Pedersen, Nancy L. (author)
- Karolinska Institutet
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- Magnusson, Patrik Ke (author)
- Karolinska Institutet
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- Almqvist, Catarina (author)
- Karolinska Institutet
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- Valdimarsdóttir, Unnur A. (author)
- Karolinska Institutet
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(creator_code:org_t)
- eLife Sciences Publications Ltd, 2021
- 2021
- English.
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In: eLIFE. - : eLife Sciences Publications Ltd. - 2050-084X. ; 10
- Related links:
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https://doi.org/10.7...
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https://urn.kb.se/re...
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https://doi.org/10.7...
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Abstract
Subject headings
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- Twins suffering a co-twin loss at birth have reported feelings of loneliness and grief while it remains unexplored if they suffer increased risk of psychiatric disorders. We contrasted rate of first-onset psychiatric disorders among all Swedish-born twins whose co-twin died within 60 days after birth between 1973 and 2011 (n = 787) to that of 3935 matched unexposed twins, 3935 matched singletons (both matched to the exposed twins by birth year, sex, and birth characteristics), and 880 full siblings of the exposed twins. During a median of 19-year follow-up, exposed twins were at increased risk of first-onset psychiatric disorders (hazard ratio = 1.56, 95%CI 1.30-1.87) compared with unexposed twins. We observed the strongest association for emotional disorders and for psychiatric disorders diagnosed before the age of 25. Comparisons with matched singletons and the twin's full siblings rendered similar results, corroborating an association of loss of a co-twin at birth with subsequent risk of psychiatric disorders.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Early twin loss
- epidemiology
- family design
- global health
- human
- psychatric disorder
Publication and Content Type
- ref (subject category)
- art (subject category)
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