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Validation of clini...
Validation of clinical clusters for long-term mortality in two European COPD cohorts
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- Gagatek, Sebastian Grzegorz (författare)
- Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden
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- Wijnant, Sara (författare)
- Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
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- Ställberg, Björn (författare)
- Department of Public Health and Caring Sciences, Family Medicine and Preventive medicine, Uppsala University, Uppsala, Sweden
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- Lisspers, Karin (författare)
- Department of Public Health and Caring Sciences, Family Medicine and Preventive medicine, Uppsala University, Uppsala, Sweden
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- Brusselle, Guy (författare)
- Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
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- Zhou, Xing Wu (författare)
- Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden
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- Hasselgren, Mikael, 1964- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Montgomery, Scott, 1961- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology and Biostatistics
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- Sundh, Josefin, 1972- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Respiratory Medicine
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- Christer, Janson (författare)
- Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden
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- Emilsson, Össur (författare)
- Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden
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- Lahousse, Lies (författare)
- Department of Epidemiology, Erasmus Medical Centre, Rotterdam, Netherlands
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- Malinovschi, Andrei (författare)
- Department of Medical Sciences: Clinical Physiology, Uppsala University, Uppsala, Sweden
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(creator_code:org_t)
- 2020-10-28
- 2020
- Engelska.
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Ingår i: European Respiratory Journal. - : European Respiratory Society. - 0903-1936 .- 1399-3003. ; 56:Suppl. 64
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous disease with a variable mortality risk. A simple clinical algorithm has been validated for short-term mortality by Burgel et al. (ERJ 2017).Aim: To study if Burgel’s clinical algorithm is valid to predict long-term mortality.Methods: Data from two COPD cohorts, the Swedish PRAXIS Study (PS) (n=784, mean age (SD) 64.0 years (7.5), 42% males) and the Rotterdam Study (RS) (n=735, mean age (SD) 72 years (9.2), 57% males), with 9-years of follow-up data including mortality was used. The five clinical clusters were derived from baseline data on age, body mass index, dyspnea grade (mMRC), FEV 1 (%pred) and comorbidity (cardiovascular disease or diabetes). Mortality risk was estimated by unadjusted Cox models.Results: The distribution of clinical clusters (1-5) was: 29%/45%/8%/6%/12% in PS and 23%/26%/36%/0/15% in RS. The cumulative proportion of deaths after 9-years of follow-up was highest among COPD clusters 1 (65%) and 4 (72%), and lowest among cluster 5 (10%) in the PS cohort. In RS, Cluster 1 (44%) had the highest cumulative mortality and cluster 5 (5%) the lowest. Compared to cluster 5, the meta-analysed hazard ratio (HR) (95%CI) for cluster 1 was 9.95 (6.52–15.19) and for cluster 4, 13.49 (6.41–28.38). The meta-analysed HR for clusters 2 and 3, compared with cluster 5, were: 2.80 (1.77 – 4.36) and 4.73 (3.02 – 7.42), respectively.Conclusions: Burgel’s clinical clusters can be used to predict long-term mortality risk. Clusters 1 and 4 are associated with the poorest prognosis, cluster 5 with best prognosis and clusters 2 and 3 with intermediate prognosis in two independent COPD cohorts from Sweden and Netherlands.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- COPD
- Comorbidities
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Gagatek, Sebasti ...
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Wijnant, Sara
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Ställberg, Björn
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Lisspers, Karin
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Brusselle, Guy
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Zhou, Xing Wu
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Hasselgren, Mika ...
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Montgomery, Scot ...
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Sundh, Josefin, ...
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Christer, Janson
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Emilsson, Össur
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Lahousse, Lies
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Malinovschi, And ...
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