id:"swepub:oai:DiVA.org:oru-93617"
Search: id:"swepub:oai:DiVA.org:oru-93617" > Adult-onset inflamm...
- 1 of 1
- Previous record
- Next record
- To hitlist
Adult-onset inflammatory bowel disease and rate of serious infections compared to the general population : a nationwide register-based cohort study 2002-2017
-
- Ludvigsson, Jonas F., 1969- (author)
- Karolinska Institutet
-
- Holmgren, Johanna (author)
- Department of Gastroenterology, Skåne University Hospital, Malmö, Sweden
-
- Grip, Olof (author)
- Department of Gastroenterology, Skåne University Hospital, Malmö, Sweden
- show more...
- show less...
- (creator_code:org_t)
- 2021-08-08
- 2021
- English.
- In: Scandinavian Journal of Gastroenterology. - : Taylor & Francis. - 0036-5521 .- 1502-7708. ; 56:10, s. 1152-1162
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- OBJECTIVES: To investigate absolute and relative risk of serious infections in adult/elderly inflammatory bowel disease (IBD) diagnosed 2002-2017.METHODS: Nationwide, register-based cohort study of Swedish patients with IBD compared with general population matched reference individuals with regard to time to first serious infection, equal to hospital admission. Multivariable Cox regression estimated hazard ratios (HRs) for any serious infection. Secondary outcomes included site-specific infections, opportunistic infections and sepsis.RESULTS: We identified 47 798 individuals with IBD. During a follow-up of 329 000 person-years, they had 8752 first serious infections (26.6 per 1000 person-years). This compared with an incidence rate of 10.7 per 1000 person-years in matched reference individuals, corresponding to a 2.53-fold increased hazard of serious infections (95%CI = 2.47-2.59). The HR for serious infection in elderly-onset IBD was 2.01 (95%CI = 1.95-2.08). The relative hazard of serious infection was somewhat higher in Crohn's disease (2.94; 95%CI = 2.81-3.06) than in ulcerative colitis (2.24; 95%CI = 2.17-2.31). The HR for serious infections was high in the first year of follow-up (5.17; 95%CI = 4.93-5.42). Individuals with IBD were at a particularly high relative hazard of gastrointestinal and opportunistic infections. The HR for sepsis was 2.47 (95%CI = 2.32-2.63). The relative rates for serious infections in IBD increased in recent years.CONCLUSIONS: Patients with adult-onset IBD are at increased risk of serious infections, particularly gastrointestinal and opportunistic infections. Relative rates were highest just after IBD diagnosis, and seem to have increased in recent years.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- Crohn’s disease
- IBD
- IBD unclassified
- indeterminate IBD
- ulcerative colitis
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Scandinavian Journal of Gastroenterology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Ludvigsson, Jona ...
- Holmgren, Johann ...
- Grip, Olof
- Halfvarson, Jona ...
- Askling, Johan
- Sachs, Michael C ...
- show more...
- Olén, Ola
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Gastroenterology ...
- Articles in the publication
- Scandinavian Jou ...
- By the university
- Örebro University
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
