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Statin Therapy is Associated with Decreased 90-day Postoperative Mortality After Colon Cancer Surgery
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- Pourlotfi, Arvid, 1995- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Surgery, Örebro University Hospital, Örebro, Sweden
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- Ahl, Rebecka, 1987- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Surgery, Karolinska University Hospital, Stockholm, Sweden
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- Bass, Gary Alan, 1979- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Surgical Critical Care & Emergency Surgery, Penn Medicine, Penn Presbyterian Medical Center, Philadelphia, USA
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- (creator_code:org_t)
- Springer, 2022
- 2022
- English.
- In: Diseases of the Colon & Rectum. - : Springer. - 0012-3706 .- 1530-0358. ; 65:4, s. 559-565
- Journal article (peer-reviewed)
Abstract
Subject headings
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- BACKGROUND: There have been conflicting reports regarding a protective effect of statin therapy after colon cancer surgery.OBJECTIVE: This study aimed to evaluate the association between statin therapy and the postoperative mortality following elective colon cancer surgery.DESIGN: This population-based cohort study is a retrospective analysis of prospectively collected data from the Swedish Colorectal Cancer Register.SETTINGS: Patient inclusion was achieved by inclusion through a nationwide register.PATIENTS: All adult patients undergoing elective surgery for colon cancer between the period of January 2007 and September 2016 were included in the study. Patients who had received and collected a prescription for statins pre- and postoperatively were allocated to the statin positive cohort.MAIN OUTCOME MEASURES: The primary and secondary outcomes of interest were 90-day all-cause mortality and 90-day cause-specific mortality.RESULTS: A total of 22,337 patients underwent elective surgery for colon cancer during the study period, of whom 6,494 (29%) were classified as statin users. Statin users displayed a significant survival benefit despite being older, having a higher comorbidity burden, and less fit for surgery. Multivariate analysis illustrated significant reductions in the incidence risk for 90-day all-cause mortality (Incidence Rate Ratio = 0.12, p < 0.001) as well as 90-day cause-specific deaths due to sepsis, multiorgan failure, or of cardiovascular and respiratory origin.LIMITATIONS: The limitations of this study include its observational retrospective design, restricting the ability to perform standardized follow-up of statin therapy. Confounding from other uncontrolled variables cannot be excluded.CONCLUSIONS: Statin users had a significant postoperative benefit regarding short-term mortality following elective colon cancer surgery in the current study, however, further research is needed to ascertain if this relationship is causal. See Video Abstract at http://links.lww.com/DCR/B738.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Colon cancer
- Mortality
- Postoperative
- Statins
- Surgery
Publication and Content Type
- ref (subject category)
- art (subject category)
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