Association of blaVIM-2, blaPDC-35, blaOXA-10, blaOXA-488 and blaVEB-9 β-Lactamase Genes with Resistance to Ceftazidime-Avibactam and Ceftolozane-Tazobactam in Multidrug-Resistant Pseudomonas aeruginosa

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Association of blaVIM-2, blaPDC-35, blaOXA-10, blaOXA-488 and blaVEB-9 β-Lactamase Genes with Resistance to Ceftazidime-Avibactam and Ceftolozane-Tazobactam in Multidrug-Resistant Pseudomonas aeruginosa

Sid Ahmed, Mazen, 1970- (author): Örebro universitet,Institutionen för naturvetenskap och teknik,Department of Laboratory Medicine and Pathology, Microbiology Division, Hamad Medical Corporation, Doha, Qatar,The Life Science Centre-Biology

Khan, Faisal Ahmad, 1986- (author): Örebro universitet,Institutionen för naturvetenskap och teknik,The Life Science Centre-Biology

Hadi, Hamad Abdel (author): Communicable Diseases Center, Hamad Medical Corporation, Doha, Qatar; Division of Infectious Diseases, Department of Medicine, Hamad Medical Corporation, Doha, Qatar

Skariah, Sini (author): Department of Microbiology and Immunology, Weill Cornell Medicine-Qatar, Doha, Qatar

Sultan, Ali A. (author): Department of Microbiology and Immunology, Weill Cornell Medicine-Qatar, Doha, Qatar

Salam, Abdul (author): Department of Epidemiology and Biostatistics, King Fahad Specialist Hospital, Dammam, Saudi Arabia

Al Khal, Abdul Latif (author): Communicable Diseases Center, Hamad Medical Corporation, Doha, Qatar; Division of Infectious Diseases, Department of Medicine, Hamad Medical Corporation, Doha, Qatar

Söderquist, Bo, 1955- (author): Örebro universitet,Institutionen för medicinska vetenskaper

Ibrahim, Emad Bashir (author): Department of Laboratory Medicine and Pathology, Microbiology Division, Hamad Medical Corporation, Doha, Qatar; Department of Microbiology and Immunology, Weill Cornell Medicine-Qatar, Doha, Qatar

Omrani, Ali S (author)

Jass, Jana, 1963- (author): Örebro universitet,Institutionen för naturvetenskap och teknik,The Life Science Centre-Biology

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2022-01-19
2022
English.
In: Antibiotics. - : MDPI. - 2079-6382. ; 11:2

Related links:: https://doi.org/10.3...; show more...; https://www.mdpi.com...; https://urn.kb.se/re...; https://doi.org/10.3...; show less...

Journal article (peer-reviewed)

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Ceftazidime-avibactam and ceftolozane-tazobactam are approved for the treatment of complicated Gram-negative bacterial infections including multidrug-resistant (MDR) Pseudomonas aeruginosa. Resistance to both agents has been reported, but the underlying mechanisms have not been fully explored. This study aimed to correlate β-lactamases with phenotypic resistance to ceftazidime-avibactam and/or ceftolozane-tazobactam in MDR-P. aeruginosa from Qatar. A total of 525 MDR-P. aeruginosa isolates were collected from clinical specimens between 2014 and 2017. Identification and antimicrobial susceptibility were performed by the BD PhoenixTM system and gradient MIC test strips. Of the 75 sequenced MDR isolates, 35 (47%) were considered as having difficult-to-treat resistance, and 42 were resistant to ceftazidime-avibactam (37, 49.3%), and/or ceftolozane-tazobactam (40, 53.3%). They belonged to 12 sequence types, with ST235 being predominant (38%). Most isolates (97.6%) carried one or more β-lactamase genes, with blaOXA-488 (19%) and blaVEB-9 (45.2%) being predominant. A strong association was detected between class B β-lactamase genes and both ceftazidime-avibactam and ceftolozane-tazobactam resistance, while class A genes were associated with ceftolozane-tazobactam resistance. Co-resistance to ceftazidime-avibactam and ceftolozane-tazobactam correlated with the presence of blaVEB-9, blaPDC-35, blaVIM-2, blaOXA-10 and blaOXA-488. MDR-P. aeruginosa isolates resistant to both combination drugs were associated with class B β-lactamases (blaVIM-2) and class D β-lactamases (blaOXA-10), while ceftolozane-tazobactam resistance was associated with class A (blaVEB-9), class C (blaVPDC-35), and class D β-lactamases (blaOXA-488).

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By the author/editor: Sid Ahmed, Mazen ...; Khan, Faisal Ahm ...; Hadi, Hamad Abde ...; Skariah, Sini; Sultan, Ali A.; Salam, Abdul; show more...; Al Khal, Abdul L ...; Söderquist, Bo, ...; Ibrahim, Emad Ba ...; Omrani, Ali S; Jass, Jana, 1963 ...; show less...

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NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Microbiology

Articles in the publication: Antibiotics

By the university: Örebro University

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Association of blaVIM-2, blaPDC-35, blaOXA-10, blaOXA-488 and blaVEB-9 β-Lactamase Genes with Resistance to Ceftazidime-Avibactam and Ceftolozane-Tazobactam in Multidrug-Resistant Pseudomonas aeruginosa

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