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Sökning: id:"swepub:oai:DiVA.org:oru-98978" > Genomic surveillanc...

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FältnamnIndikatorerMetadata
00005220naa a2200409 4500
001oai:DiVA.org:oru-98978
003SwePub
008220512s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-989782 URI
0247 a https://doi.org/10.1093/jac/dkac1582 DOI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Golparian, Daniel,d 1984-u Örebro universitet,Institutionen för medicinska vetenskaper,World Health Organization Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, Department of Laboratory Medicine, Microbiology4 aut0 (Swepub:oru)degn
2451 0a Genomic surveillance and antimicrobial resistance in Neisseria gonorrhoeae isolates in Bangkok, Thailand in 2018
264 c 2022-05-11
264 1b Oxford University Press,c 2022
338 a print2 rdacarrier
500 a Funding agencies:Örebro County Council Research CommitteeFoundation for Medical Research at Örebro University Hospital, Sweden
520 a OBJECTIVES: Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is a substantial global public health problem. Gonococcal infections acquired in or from Asia represent most verified ceftriaxone treatment failures, and several ceftriaxone-resistant strains have emerged in Asia and subsequently spread globally. Additionally, in Thailand the gonorrhoea incidence remains high. Herein, we investigate the genomic diversity, AMR and AMR determinants in gonococcal isolates cultured in 2018 in Bangkok, Thailand.METHODS: Gonococcal isolates from males (n = 37) and females (n = 62) were examined by Etest and WGS. AMR determinants and molecular epidemiological STs were characterized. For phylogenomic comparison, raw sequence data were included from China (432 isolates), Japan (n = 270), Vietnam (n = 229), Thailand (n = 3), a global dataset (n = 12 440) and the 2016 WHO reference strains plus WHO Q (n = 15).RESULTS: In total, 88, 66 and 41 different NG-MAST, NG-STAR and MLST STs, respectively, and 31 different NG-STAR clonal complexes were found. A remarkably high frequency (88%) of β-lactamase TEM genes was detected and two novel TEM alleles were found. The phylogenomic analysis divided the isolates into the previously described lineages A and B, with a large proportion of Thai isolates belonging to the novel sublineage A3.CONCLUSIONS: We describe the first molecular epidemiological study using WGS on gonococcal isolates from Thailand. The high prevalence of AMR and AMR determinants for ciprofloxacin, tetracycline and benzylpenicillin, and some strains belonging to clones/clades especially in sublineage A2 that are prone to develop resistance to extended-spectrum cephalosporins (ESCs) and azithromycin, should prompt continued and strengthened AMR surveillance, including WGS, of N. gonorrhoeae in Thailand.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
7001 a Kittiyaowamarn, Rossaphornu Bangrak STIs Center, Division of AIDS and STIs, Department of Disease Control, Ministry of Public Health, Bangkok, Thailand4 aut
7001 a Paopang, Porntipu Bangrak STIs Center, Division of AIDS and STIs, Department of Disease Control, Ministry of Public Health, Bangkok, Thailand4 aut
7001 a Sangprasert, Pongsathornu Bangrak STIs Center, Division of AIDS and STIs, Department of Disease Control, Ministry of Public Health, Bangkok, Thailand4 aut
7001 a Sirivongrangson, Pacharau Department of Disease Control, Ministry of Public Health, Bangkok, Thailan4 aut
7001 a Franceschi, Francoisu Global Antibiotic Research & Development Partnership (GARDP), Geneva, Switzerland4 aut
7001 a Jacobsson, Susanne,d 1974-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,World Health Organization Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, Department of Laboratory Medicine, Microbiology4 aut0 (Swepub:oru)sajn
7001 a Wi, Teodorau Department of the Global HIV, Hepatitis and STI programmes, World Health Organization, Geneva, Switzerland4 aut
7001 a Unemo, Magnus,d 1970-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,World Health Organization Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, Department of Laboratory Medicine, Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Institute for Global Health, University College London, London, UK4 aut0 (Swepub:oru)muo
7102 a Örebro universitetb Institutionen för medicinska vetenskaper4 org
7730 t Journal of Antimicrobial Chemotherapyd : Oxford University Pressg 77:8, s. 2171-2182q 77:8<2171-2182x 0305-7453x 1460-2091
8564 u https://doi.org/10.1093/jac/dkac158y Fulltext
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-98978
8564 8u https://doi.org/10.1093/jac/dkac158

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