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Hybrid origins and ...
Hybrid origins and the earliest stages of diploidization in the highly successful recent polyploid Capsella bursa-pastoris
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Douglas, Gavin M. (author)
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Gos, Gesseca (author)
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- Steige, Kim A. (author)
- Uppsala universitet,Evolutionsbiologi,Science for Life Laboratory, SciLifeLab
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Salcedo, Adriana (author)
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- Holm, Karl (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Växtekologi och evolution
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Josephs, Emily B. (author)
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Arunkumar, Ramesh (author)
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Agren, J. Arvid (author)
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Hazzouri, Khaled M. (author)
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Wang, Wei (author)
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Platts, Adrian E. (author)
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Williamson, Robert J. (author)
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Neuffer, Barbara (author)
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- Lascoux, Martin (author)
- Uppsala universitet,Växtekologi och evolution,Science for Life Laboratory, SciLifeLab
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- Slotte, Tanja (author)
- Uppsala universitet,Stockholms universitet,Institutionen för ekologi, miljö och botanik,Uppsala University, Sweden,Evolutionsbiologi
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Wright, Stephen I. (author)
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(creator_code:org_t)
- 2015-02-17
- 2015
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 112:9, s. 2806-2811
- Related links:
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https://www.pnas.org...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Whole-genome duplication (WGD) events have occurred repeatedly during flowering plant evolution, and there is growing evidence for predictable patterns of gene retention and loss following polyploidization. Despite these important insights, the rate and processes governing the earliest stages of diploidization remain poorly understood, and the relative importance of genetic drift, positive selection, and relaxed purifying selection in the process of gene degeneration and loss is unclear. Here, we conduct whole-genome resequencing in Capsella bursa-pastoris, a recently formed tetraploid with one of the most widespread species distributions of any angiosperm. Whole-genome data provide strong support for recent hybrid origins of the tetraploid species within the past 100,000-300,000 y from two diploid progenitors in the Capsella genus. Major-effect inactivating mutations are frequent, but many were inherited from the parental species and show no evidence of being fixed by positive selection. Despite a lack of large-scale gene loss, we observe a decrease in the efficacy of natural selection genome-wide due to the combined effects of demography, selfing, and genome redundancy from WGD. Our results suggest that the earliest stages of diploidization are associated with quantitative genome-wide decreases in the strength and efficacy of selection rather than rapid gene loss, and that non-functionalization can receive a head start through a legacy of deleterious variants and differential expression originating in parental diploid populations.
Subject headings
- NATURVETENSKAP -- Geovetenskap och miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- polyploidy
- population genomics
- speciation
- gene loss
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Douglas, Gavin M ...
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Gos, Gesseca
-
Steige, Kim A.
-
Salcedo, Adriana
-
Holm, Karl
-
Josephs, Emily B ...
-
show more...
-
Arunkumar, Rames ...
-
Agren, J. Arvid
-
Hazzouri, Khaled ...
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Wang, Wei
-
Platts, Adrian E ...
-
Williamson, Robe ...
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Neuffer, Barbara
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Lascoux, Martin
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Slotte, Tanja
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Wright, Stephen ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Earth and Relate ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
- Articles in the publication
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Proceedings of t ...
- By the university
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Stockholm University
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Uppsala University