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The Environmental P...
The Environmental Pollutants Perfluorooctane Sulfonate and Perfluorooctanoic Acid Upregulate Uncoupling Protein 1 (UCP1) in Brown-Fat Mitochondria Through a UCP1-Dependent Reduction in Food Intake
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- Shabalina, Irina G. (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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- Kramarova, Tatiana V. (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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- Mattsson, Charlotte L. (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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- Petrovic, Natasa (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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- Qazi, Mousumi Rahman (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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- Csikasz, Robert I. (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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Chang, Shu-Ching (author)
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Butenhoff, John (author)
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- DePierre, Joseph W. (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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- Cannon, Barbara (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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- Nedergaard, Jan (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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(creator_code:org_t)
- 2015-05-21
- 2015
- English.
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In: Toxicological Sciences. - : Oxford University Press (OUP). - 1096-6080 .- 1096-0929. ; 146:2, s. 334-343
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The environmental pollutants perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) cause a dramatic reduction in the size of the major adipose tissue depots and a general body weight decrease when they are added to the food of mice. We demonstrate here that this is mainly due to a reduction in food intake; this reduction was not due to food aversion. Remarkably and unexpectedly, a large part of the effect of PFOA/PFOS on food intake was dependent on the presence of the uncoupling protein 1 (UCP1) in the mice. Correspondingly, PFOA/PFOS treatment induced recruitment of brown adipose tissue mitochondria: increased oxidative capacity and increased UCP1-mediated oxygen consumption (thermogenesis). In mice pair-fed to the food intake during PFOA/PFOS treatment in wildtype mice, brown-fat mitochondrial recruitment was also induced. We conclude that we have uncovered the existence of a regulatory component of food intake that is dependent upon brown adipose tissue thermogenic activity. The possible environmental consequences of this novel PFOA/PFOS effect (a possible decreased fitness) are noted, as well as the perspectives of this finding on the general understanding of control of food intake control and its possible extension to combatting obesity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- thermogenesis
- food restriction
- adipose tissue
- fatty acid oxidation
- body temperature
Publication and Content Type
- ref (subject category)
- art (subject category)
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Shabalina, Irina ...
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Kramarova, Tatia ...
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Mattsson, Charlo ...
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Petrovic, Natasa
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Qazi, Mousumi Ra ...
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Csikasz, Robert ...
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show more...
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Chang, Shu-Ching
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Butenhoff, John
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DePierre, Joseph ...
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Cannon, Barbara
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Nedergaard, Jan
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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Toxicological Sc ...
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Stockholm University