id:"swepub:oai:DiVA.org:su-136042"
Sökning: id:"swepub:oai:DiVA.org:su-136042" > Radiation track, DN...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Radiation track, DNA damage and response-a review
-
- Nikjoo, H. (författare)
- Karolinska Institutet
- Emfietzoglou, D. (författare)
- Liamsuwan, T. (författare)
- visa fler...
- Taleei, R. (författare)
- Uehara, S. (författare)
- visa färre...
- (creator_code:org_t)
- 2016-09-21
- 2016
- Engelska.
- Ingår i: Reports on progress in physics (Print). - : IOP Publishing. - 0034-4885 .- 1361-6633. ; 79:11
- Forskningsöversikt (refereegranskat)
Abstract
Ämnesord
Stäng
- The purpose of this paper has been to review the current status and progress of the field of radiation biophysics, and draw attention to the fact that physics, in general, and radiation physics in particular, with the aid of mathematical modeling, can help elucidate biological mechanisms and cancer therapies. We hypothesize that concepts of condensed-matter physics along with the new genomic knowledge and technologies and mechanistic mathematical modeling in conjunction with advances in experimental DNA (Deoxyrinonucleic acid molecule) repair and cell signaling have now provided us with unprecedented opportunities in radiation biophysics to address problems in targeted cancer therapy, and genetic risk estimation in humans. Obviously, one is not dealing with 'low-hanging fruit', but it will be a major scientific achievement if it becomes possible to state, in another decade or so, that we can link mechanistically the stages between the initial radiation-induced DNA damage; in particular, at doses of radiation less than 2 Gy and with structural changes in genomic DNA as a precursor to cell inactivation and/or mutations leading to genetic diseases. The paper presents recent development in the physics of radiation track structure contained in the computer code system KURBUC, in particular for low-energy electrons in the condensed phase of water for which we provide a comprehensive discussion of the dielectric response function approach. The state-of-the-art in the simulation of proton and carbon ion tracks in the Bragg peak region is also presented. The paper presents a critical discussion of the models used for elastic scattering, and the validity of the trajectory approach in low-electron transport. Brief discussions of mechanistic and quantitative aspects of microdosimetry, DNA damage and DNA repair are also included as developed by the authors' work.
Ämnesord
- NATURVETENSKAP -- Fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences (hsv//eng)
Nyckelord
- track structure
- radiation biophysics
- DNA damage
- DNA repair
- inelastic scattering
- elastic scattering
- microdosimetry
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
Hitta via bibliotek
- Reports on progress in physics (Print) (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Nikjoo, H.
- Emfietzoglou, D.
- Liamsuwan, T.
- Taleei, R.
- Liljequist, Davi ...
- Uehara, S.
- Om ämnet
-
- NATURVETENSKAP
- NATURVETENSKAP
- och Fysik
- Artiklar i publikationen
- Reports on progr ...
- Av lärosätet
- Stockholms universitet
- Karolinska Institutet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
