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Impact of disease duration and cardiovascular dysautonomia on hypertension in Parkinson's disease

Vetrano, Davide L. (author)
Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Catholic University of Rome, Italy
Pisciotta, Maria S. (author)
Brandi, Vincenzo (author)
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Lo Monaco, Maria R. (author)
Laudisio, Alice (author)
Onder, Graziano (author)
Fusco, Domenico (author)
L'Angiocola, Paolo D. (author)
Bentivoglio, Anna R. (author)
Bernabei, Roberto (author)
Zuccalà, Giuseppe (author)
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 (creator_code:org_t)
2016-11-02
2017
English.
In: The Journal of Clinical Hypertension. - : Wiley. - 1524-6175 .- 1751-7176. ; 19:4, s. 418-423
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The authors evaluated the association of Parkinson's disease (PD) duration with hypertension, assessed by office measurements and 24-hour (ambulatory) monitoring, in 167 patients. Hypertension was evaluated through both office and ambulatory blood pressure (BP) measurements. Among participants (mean age 73.4 +/- 7.6years; 35% women), the prevalence of hypertension was 60% and 69% according to office and ambulatory BP measurements, respectively (Cohen's k=0.61; P<.001). PD duration was inversely associated with hypertension as diagnosed by office measurements (odds ratio [OR], 0.92; 95% confidence interval [CI], 0.86-0.98) but not by ambulatory monitoring (OR, 0.94; 95% CI, 0.81-1.01). Ambulatory BP patterns showed higher nocturnal BP among patients with long-lasting disease. In conclusion, ambulatory BP monitoring improves the detection of hypertension by 15% in PD, compared with office evaluation. The likelihood of having hypertension does not decrease during the PD course; rather, BP pattern shifts towards nocturnal hypertension.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Keyword

ambulatory blood pressure monitoring
dysautonomia
hypertension
non-motor symptoms
Parkinsons disease

Publication and Content Type

ref (subject category)
art (subject category)

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