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Prototypical pacema...
Prototypical pacemaker neurons interact with the resident microbiota
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- Klimovich, Alexander (author)
- Univ Kiel, Zool Inst, Dept Cell & Dev Biol, D-24118 Kiel, Germany.
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- Giacomello, Stefania (author)
- KTH,Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Kungliga Tekniska Högskolan (Royal Institute of Technology), Sweden,Science for Life Laboratory, SciLifeLab,Genteknologi,Stockholm Univ, Natl Infrastruct Sweden, Sci Life Lab, Dept Biochem & Biophys, S-17121 Solna, Sweden.;Kungligia Tekn Högskolan Royal Inst Technol, Sci Life Lab, Dept Gene Technol, S-17121 Solna, Sweden.
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- Björklund, Åsa (author)
- Uppsala universitet,Molekylär evolution,Science for Life Laboratory, SciLifeLab
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- Faure, Louis (author)
- Med Univ Vienna, Ctr Brain Res, Dept Mol Neurosci, A-1090 Vienna, Austria.
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- Kaucka, Marketa (author)
- Med Univ Vienna, Ctr Brain Res, Dept Mol Neurosci, A-1090 Vienna, Austria.;Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden.;Max Planck Inst Evolutionary Biol, Dept Evolutionary Genet, SH 24306 Plon, SH-24306 Plon, Germany.
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- Giez, Christoph (author)
- Univ Kiel, Zool Inst, Dept Cell & Dev Biol, D-24118 Kiel, Germany.
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- Murillo-Rincon, Andrea P. (author)
- Univ Kiel, Zool Inst, Dept Cell & Dev Biol, D-24118 Kiel, Germany.
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- Matt, Ann-Sophie (author)
- Univ Kiel, Zool Inst, Dept Cell & Dev Biol, D-24118 Kiel, Germany.
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- Willoweit-Ohl, Doris (author)
- Univ Kiel, Zool Inst, Dept Cell & Dev Biol, D-24118 Kiel, Germany.
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- Crupi, Gabriele (author)
- Univ Kiel, Zool Inst, Dept Cell & Dev Biol, D-24118 Kiel, Germany.
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- de Anda, Jaime (author)
- Univ Calif Los Angeles, Calif NanoSyst Inst, Dept Bioengn, Los Angeles, CA 90095 USA.;Univ Calif Los Angeles, Calif NanoSyst Inst, Dept Chem & Biochem, Los Angeles, CA 90095 USA.
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- Wong, Gerard C. L. (author)
- Univ Calif Los Angeles, Calif NanoSyst Inst, Dept Bioengn, Los Angeles, CA 90095 USA.;Univ Calif Los Angeles, Calif NanoSyst Inst, Dept Chem & Biochem, Los Angeles, CA 90095 USA.
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- D'Amato, Mauro (author)
- Monash Univ, Sch Biol Sci, Clayton, Vic 3800, Australia.
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- Adameyko, Igor (author)
- Karolinska Institutet
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Bosch, Thomas C. G. (author)
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Univ Kiel, Zool Inst, Dept Cell & Dev Biol, D-24118 Kiel, Germany Institutionen för biokemi och biofysik (creator_code:org_t)
- 2020-07-09
- 2020
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 117:30, s. 17854-17863
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https://www.pnas.org...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Pacemaker neurons exert control over neuronal circuit function by their intrinsic ability to generate rhythmic bursts of action potential. Recent work has identified rhythmic gut contractions in human, mice, and hydra to be dependent on both neurons and the resident microbiota. However, little is known about the evolutionary origin of these neurons and their interaction with microbes. In this study, we identified and functionally characterized prototypical ANO/SCN/TRPMion channel-expressing pacemaker cells in the basal metazoan Hydra by using a combination of single-cell transcriptomics, immunochemistry, and functional experiments. Unexpectedly, these prototypical pacemaker neurons express a rich set of immune-related genes mediating their interaction with the microbial environment. Furthermore, functional experiments gave a strong support to a model of the evolutionary emergence of pacemaker cells as neurons using components of innate immunity to interact with the microbial environment and ion channels to generate rhythmic contractions.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Keyword
- pacemaker neuron
- Hydra
- ion channel
- microbiome
- antimicrobial peptide
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Klimovich, Alexa ...
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Giacomello, Stef ...
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Björklund, Åsa
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Faure, Louis
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Kaucka, Marketa
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Giez, Christoph
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show more...
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Murillo-Rincon, ...
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Matt, Ann-Sophie
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Willoweit-Ohl, D ...
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Crupi, Gabriele
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de Anda, Jaime
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Wong, Gerard C. ...
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D'Amato, Mauro
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Adameyko, Igor
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Bosch, Thomas C. ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
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Proceedings of t ...
- By the university
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Stockholm University
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Royal Institute of Technology
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Uppsala University
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Karolinska Institutet