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Assessment of the p...
Assessment of the probability of tumour control for prescribed doses based on imaging of oxygen partial pressure
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- Ureba, Ana (författare)
- Karolinska Institutet
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- Kjellsson Lindblom, Emely (författare)
- Stockholms universitet,Fysikum,Karolinska Institutet, Sweden
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- Toma-Dasu, Iuliana (författare)
- Stockholms universitet,Fysikum,Karolinska Institutet, Sweden
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- Dasu, Alexandru, 1972- (författare)
- Uppsala universitet,Medicinsk strålningsvetenskap
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- Lazzeroni, Marta (författare)
- Stockholms universitet,Fysikum,Karolinska Institutet, Sweden
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Nemoto, EM (författare)
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Harrison, EM (författare)
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Pias, SC (författare)
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Bragin, DE (författare)
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Harrison, DK (författare)
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LaManna, JC (författare)
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(creator_code:org_t)
- 2021-05-09
- 2021
- Engelska.
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Ingår i: Oxygen Transport to Tissue XLII. - Cham : Springer. - 9783030482367 - 9783030482381 ; 1269, s. 185-190
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- In radiotherapy, hypoxia is a known negative factor, occurring especially in solid malignant tumours. Nitroimidazole-based positron emission tomography (PET) tracers, due to their selective binding to hypoxic cells, could be used as surrogates to image and quantify the underlying oxygen distributions in tissues. The spatial resolution of a clinical PET image, however, is much larger than the cellular spatial scale where hypoxia occurs. A question therefore arises regarding the possibility of quantifying different hypoxia levels based on PET images, and the aim of the present study is the prescription of corresponding therapeutic doses and its exploration.A tumour oxygenation model was created consisting of two concentric spheres with different oxygen partial pressure (pO2) distributions. In order to mimic a PET image of the simulated tumour, given the relation between uptake and pO2, fundamental effects that limit spatial resolution in a PET imaging system were considered: the uptake distribution was processed with a Gaussian 3D filter, and a re-binning to reach a typical PET image voxel size was performed. Prescription doses to overcome tumour hypoxia and predicted tumour control probability (TCP) were calculated based on the processed images for several fractionation schemes. Knowing the underlying oxygenation at microscopic scale, the actual TCP expected after the delivery of the calculated prescription doses was evaluated. Results are presented for three different dose painting strategies: by numbers, by contours and by using a voxel grouping-based approach.The differences between predicted TCP and evaluated TCP indicate that careful consideration must be taken on the dose prescription strategy and the selection of the number of fractions, depending on the severity of hypoxia.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Dose painting
- Hypoxia
- Mathematical modelling
- TCP
- PET
Publikations- och innehållstyp
- ref (ämneskategori)
- kap (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Ureba, Ana
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Kjellsson Lindbl ...
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Toma-Dasu, Iulia ...
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Dasu, Alexandru, ...
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Lazzeroni, Marta
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Nemoto, EM
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visa fler...
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Harrison, EM
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Pias, SC
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Bragin, DE
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Harrison, DK
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LaManna, JC
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Oxygen Transport ...
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Advances in Expe ...
- Av lärosätet
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Stockholms universitet
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Uppsala universitet
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Karolinska Institutet