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Sökning: id:"swepub:oai:DiVA.org:su-193073" > Assessment of the p...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004468naa a2200553 4500
001oai:DiVA.org:su-193073
003SwePub
008210510s2021 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-442097
009oai:prod.swepub.kib.ki.se:148804359
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1930732 URI
0247 a https://doi.org/10.1007/978-3-030-48238-1_292 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4420972 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1488043592 URI
040 a (SwePub)sud (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a kap2 swepub-publicationtype
1001 a Ureba, Anau Karolinska Institutet4 aut0 (Swepub:su)aureb
2451 0a Assessment of the probability of tumour control for prescribed doses based on imaging of oxygen partial pressure
264 c 2021-05-09
264 1a Cham :b Springer,c 2021
338 a print2 rdacarrier
520 a In radiotherapy, hypoxia is a known negative factor, occurring especially in solid malignant tumours. Nitroimidazole-based positron emission tomography (PET) tracers, due to their selective binding to hypoxic cells, could be used as surrogates to image and quantify the underlying oxygen distributions in tissues. The spatial resolution of a clinical PET image, however, is much larger than the cellular spatial scale where hypoxia occurs. A question therefore arises regarding the possibility of quantifying different hypoxia levels based on PET images, and the aim of the present study is the prescription of corresponding therapeutic doses and its exploration.A tumour oxygenation model was created consisting of two concentric spheres with different oxygen partial pressure (pO2) distributions. In order to mimic a PET image of the simulated tumour, given the relation between uptake and pO2, fundamental effects that limit spatial resolution in a PET imaging system were considered: the uptake distribution was processed with a Gaussian 3D filter, and a re-binning to reach a typical PET image voxel size was performed. Prescription doses to overcome tumour hypoxia and predicted tumour control probability (TCP) were calculated based on the processed images for several fractionation schemes. Knowing the underlying oxygenation at microscopic scale, the actual TCP expected after the delivery of the calculated prescription doses was evaluated. Results are presented for three different dose painting strategies: by numbers, by contours and by using a voxel grouping-based approach.The differences between predicted TCP and evaluated TCP indicate that careful consideration must be taken on the dose prescription strategy and the selection of the number of fractions, depending on the severity of hypoxia.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Dose painting
653 a Hypoxia
653 a Mathematical modelling
653 a TCP
653 a PET
7001 a Kjellsson Lindblom, Emelyu Stockholms universitet,Fysikum,Karolinska Institutet, Sweden4 aut0 (Swepub:su)emli3946
7001 a Toma-Dasu, Iulianau Stockholms universitet,Fysikum,Karolinska Institutet, Sweden4 aut0 (Swepub:su)iuda0736
7001 a Dasu, Alexandru,d 1972-u Uppsala universitet,Medicinsk strålningsvetenskap4 aut0 (Swepub:uu)aleda511
7001 a Lazzeroni, Martau Stockholms universitet,Fysikum,Karolinska Institutet, Sweden4 aut0 (Swepub:su)mala6377
7001 a Nemoto, EM4 aut
7001 a Harrison, EM4 aut
7001 a Pias, SC4 aut
7001 a Bragin, DE4 aut
7001 a Harrison, DK4 aut
7001 a LaManna, JC4 aut
7102 a Karolinska Institutetb Fysikum4 org
7730 t Oxygen Transport to Tissue XLIId Cham : Springerg 1269, s. 185-190q <185-190z 9783030482367z 9783030482381
7730 t Advances in Experimental Medicine and Biologyd Cham : Springerg 1269, s. 185-190q 1269<185-190x 0065-2598x 2214-8019
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-193073
8564 8u https://doi.org/10.1007/978-3-030-48238-1_29
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-442097
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:148804359

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