Cyanobacteria-From the Oceans to the Potential Biotechnological and Biomedical Applications

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Cyanobacteria-From the Oceans to the Potential Biotechnological and Biomedical Applications

Khalifa, Shaden A. M. (author): Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, SE-10691 Stockholm, Sweden.

El-Seedi, Hesham (author): Uppsala universitet,Farmakognosi,Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt.;Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Jiangsu, Peoples R China.

Saied, Essa M. (author): Suez Canal Univ, Fac Sci, Chem Dept, Ismailia 41522, Egypt.;Humboldt Univ, Inst Chem, Brook Taylor Str 2, D-12489 Berlin, Germany.

Jassbi, Amir Reza (author): Shiraz Univ Med Sci, Med & Nat Prod Chem Res Ctr, Shiraz 7134853734, Iran.

Jamebozorgi, Fatemeh H. (author): Shiraz Univ Med Sci, Med & Nat Prod Chem Res Ctr, Shiraz 7134853734, Iran.

Rateb, Mostafa E. (author): Univ West Scotland, Sch Comp Engn & Phys Sci, High St, Paisley PA1 2BE, Renfrew, Scotland.

Du, Ming (author): Dalian Polytech Univ, Natl Engn Res Ctr Seafood, Sch Food Sci & Technol, Dalian 116034, Peoples R China.

Abdel-Daim, Mohamed M. (author): Suez Canal Univ, Fac Vet Med, Pharmacol Dept, Ismailia 41522, Egypt.

Kai, Guo-Yin (author): Zhejiang Chinese Med Univ, Coll Pharm, Lab Med Plant Biotechnol, Hangzhou 311402, Peoples R China.

Al-Hammady, Montaser A. M. (author): NIOF, Natl Inst Oceanog & Fisheries, Cairo 11516, Egypt.

Xiao, Jianbo (author): Jinan Univ, Inst Food Safety & Nutr, Guangzhou 510632, Peoples R China.

Guo, Zhiming (author): Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Jiangsu, Peoples R China.

El-Seedi, Hesham R. (author)

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2021-04-24
2021
English.
In: Marine Drugs. - : MDPI AG. - 1660-3397. ; 19:5

Related links:: https://doi.org/10.3...; show more...; https://www.mdpi.com...; https://uu.diva-port... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.3...; https://urn.kb.se/re...; show less...

Research review (peer-reviewed)

Abstract Subject headings

Cyanobacteria are photosynthetic prokaryotic organisms which represent a significant source of novel, bioactive, secondary metabolites, and they are also considered an abundant source of bioactive compounds/drugs, such as dolastatin, cryptophycin 1, curacin toyocamycin, phytoalexin, cyanovirin-N and phycocyanin. Some of these compounds have displayed promising results in successful Phase I, II, III and IV clinical trials. Additionally, the cyanobacterial compounds applied to medical research have demonstrated an exciting future with great potential to be developed into new medicines. Most of these compounds have exhibited strong pharmacological activities, including neurotoxicity, cytotoxicity and antiviral activity against HCMV, HSV-1, HHV-6 and HIV-1, so these metabolites could be promising candidates for COVID-19 treatment. Therefore, the effective large-scale production of natural marine products through synthesis is important for resolving the existing issues associated with chemical isolation, including small yields, and may be necessary to better investigate their biological activities. Herein, we highlight the total synthesized and stereochemical determinations of the cyanobacterial bioactive compounds. Furthermore, this review primarily focuses on the biotechnological applications of cyanobacteria, including applications as cosmetics, food supplements, and the nanobiotechnological applications of cyanobacterial bioactive compounds in potential medicinal applications for various human diseases are discussed.

Subject headings

NATURVETENSKAP -- Biologi (hsv//swe)
NATURAL SCIENCES -- Biological Sciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)

Keyword

cyanobacteria
clinical trials
antioxidant
antiviral
COVID-19
dietary supplements
biotechnological applications
total synthesis

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By the author/editor: Khalifa, Shaden ...; El-Seedi, Hesham; Saied, Essa M.; Jassbi, Amir Rez ...; Jamebozorgi, Fat ...; Rateb, Mostafa E ...; show more...; Du, Ming; Abdel-Daim, Moha ...; Kai, Guo-Yin; Al-Hammady, Mont ...; Xiao, Jianbo; Guo, Zhiming; El-Seedi, Hesham ...; show less...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Pharmacology and ...

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Biochemistry and ...

Articles in the publication: Marine Drugs

By the university: Stockholm University; Uppsala University

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