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Alzheimer's disease...
Alzheimer's disease neuropathology is exacerbated following traumatic brain injury. Neuroprotection by co-administration of nanowired mesenchymal stem cells and cerebrolysin with monoclonal antibodies to amyloid beta peptide
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- Sharma, Hari Shanker (author)
- Uppsala universitet,Anestesiologi och intensivvård
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- Muresanu, Dafin F. (author)
- Univ Med & Pharm, Dept Clin Neurosci, Cluj Napoca, Romania.;RoNeuro Inst Neurol Res & Diagnost, Cluj Napoca, Romania.
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- Castellani, Rudy J. (author)
- Univ Maryland, Dept Pathol, Baltimore, MD 21201 USA.
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- Nozari, Ala (author)
- Massachusetts Gen Hosp, Anesthesiol & Intens Care, Boston, MA 02114 USA.
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- Vicente Lafuente, José (author)
- Univ Basque Country, UPV EHU, LaNCE, Dept Neurosci, Leioa, Bizkaia, Spain.
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- Buzoianu, Anca D. (author)
- Iuliu Hatieganu Univ Med & Pharm, Dept Clin Pharmacol & Toxicol, Cluj Napoca, Romania.
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- Sahib, Seaab (author)
- Univ Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA.
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- Tian, Z. Ryan (author)
- Univ Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA.
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- Bryukhovetskiy, Igor (author)
- Far Eastern Fed Univ, Sch Biomed, Dept Fundamental Med, Vladivostok, Russia.;Russian Acad Sci, Far East Branch, Natl Sci Ctr Marine Biol, Lab Pharmacol, Vladivostok, Russia.
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- Manzhulo, Igor (author)
- Far Eastern Fed Univ, Sch Biomed, Dept Fundamental Med, Vladivostok, Russia.;Russian Acad Sci, Far East Branch, Natl Sci Ctr Marine Biol, Lab Pharmacol, Vladivostok, Russia.
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- Menon, Preeti K., 1988- (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Stockholm, Sweden.
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- Patnaik, Ranjana (author)
- Banaras Hindu Univ, Indian Inst Technol, Sch Biomed Engn, Dept Biomat, Varanasi, Uttar Pradesh, India.
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- Wiklund, Lars (author)
- Uppsala universitet,Anestesiologi och intensivvård
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- Sharma, Aruna (author)
- Uppsala universitet,Anestesiologi och intensivvård
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- English.
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In: Progress in Brain Research. - : Elsevier. - 0079-6123 .- 1875-7855. ; 265, s. 1-97, s. 1-97
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Military personnel are prone to traumatic brain injury (TBI) that is one of the risk factors in developing Alzheimer's disease (AD) at a later stage. TBI induces breakdown of the blood-brain barrier (BBB) to serum proteins into the brain and leads to extravasation of plasma amyloid beta peptide (ΑβP) into the brain fluid compartments causing AD brain pathology. Thus, there is a need to expand our knowledge on the role of TBI in AD. In addition, exploration of the novel roles of nanomedicine in AD and TBI for neuroprotection is the need of the hour. Since stem cells and neurotrophic factors play important roles in TBI and in AD, it is likely that nanodelivery of these agents exert superior neuroprotection in TBI induced exacerbation of AD brain pathology. In this review, these aspects are examined in details based on our own investigations in the light of current scientific literature in the field. Our observations show that TBI exacerbates AD brain pathology and TiO2 nanowired delivery of mesenchymal stem cells together with cerebrolysin—a balanced composition of several neurotrophic factors and active peptide fragments, and monoclonal antibodies to amyloid beta protein thwarted the development of neuropathology following TBI in AD, not reported earlier.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Alzheimer's disease
- Traumatic brain injury
- Brain pathology
- Mesenchymal stem cells
- Cerebrolysin
- Nanowired delivery
- Nanomedicine
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Sharma, Hari Sha ...
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Muresanu, Dafin ...
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Castellani, Rudy ...
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Nozari, Ala
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Vicente Lafuente ...
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Buzoianu, Anca D ...
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show more...
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Sahib, Seaab
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Tian, Z. Ryan
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Bryukhovetskiy, ...
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Manzhulo, Igor
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Menon, Preeti K. ...
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Patnaik, Ranjana
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Wiklund, Lars
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Sharma, Aruna
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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Progress in Brai ...
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Nanomedicine and ...
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Stockholm University
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Uppsala University