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Association of Long-Term Body Weight Variability With Dementia : A Prospective Study
- Chen, Hui (author)
- Zhou, Tianjing (author)
-
- Guo, Jie (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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- Ji, John S. (author)
- Huang, Liyan (author)
- Zuo, Guangmin (author)
- Lv, Xiaozhen (author)
- Zheng, Yan (author)
- Hofman, Albert (author)
- Ma, Yuan (author)
- Yuan, Changzheng (author)
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- (creator_code:org_t)
- 2021-12-15
- 2021
- English.
- In: The journals of gerontology. Series A, Biological sciences and medical sciences. - : Oxford University Press (OUP). - 1079-5006 .- 1758-535X. ; 77:10, s. 2116-2122
- Journal article (peer-reviewed)
Abstract
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- Background: Body weight variability (BWV) refers to intraindividual weight loss and gain over a period. The association of long-term BWV with dementia remains unclear and whether this association is beyond body weight change is undetermined.Methods: In the Health and Retirement Study, a total of 5 547 dementia-free participants (56.7% women; mean [SD] age, 71.1 [3.2] years) at baseline (2008) were followed up to 8 years (mean = 6.8 years) to detect incident dementia. Body weight was self-reported biennially from 1992 to 2008. BWV was measured as the coefficient of variation utilizing the body weight reported 9 times across 16 years before baseline. Cox-proportional hazard model was used to estimate the hazard ratio (HR) and 95% confidence interval (CI).Results: Among the 5 547 participants, a total of 427 incident dementia cases were identified during follow-up. Greater long-term BWV was significantly associated with a higher risk of dementia (HR comparing extreme quartiles: 2.01, 95% CI: 1.48-2.72; HR of each SD increment: 1.21, 95% CI: 1.10-1.32; p-trend < .001) independent of mean body weight and body weight change. This significant association was even observed for BWV estimated approximately 15 years preceding dementia diagnosis (HR of each SD increment: 1.13, 95% CI: 1.03-1.23) and was more pronounced for that closer to diagnosis.Conclusion: Our prospective study suggested that greater BWV may be a novel risk factor for dementia.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- Body weight variability
- Cognitive impairment
- Dementia
- Healthy aging
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Chen, Hui
- Zhou, Tianjing
- Guo, Jie
- Ji, John S.
- Huang, Liyan
- Xu, Weili
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- Zuo, Guangmin
- Lv, Xiaozhen
- Zheng, Yan
- Hofman, Albert
- Ma, Yuan
- Yuan, Changzheng
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