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Polymeric Ig recept...
Polymeric Ig receptor knockout mice are more susceptible to mycobacteria infection in the respiratory tract
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- Tjärnlund, Anna (författare)
- Stockholms universitet,Avdelningen för immunologi,Wenner-Grens institut
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- Rodríguez, Ariane (författare)
- Stockholms universitet,Wenner-Grens institut
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Cardona, P J (författare)
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Guirado, E (författare)
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Ivanyi, J (författare)
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Singh, M (författare)
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Marsh, P.D. (författare)
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Williams, A (författare)
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- Troye-Blomberg, Marita (författare)
- Stockholms universitet,Avdelningen för immunologi
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Fernandez, Carmen (författare)
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(creator_code:org_t)
- 2006-03-28
- 2006
- Engelska.
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Ingår i: International Immunology. - : Oxford university press. - 0953-8178 .- 1460-2377. ; 18:5, s. 807-816
- Relaterad länk:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- It is generally accepted that cellular, and not humoral immunity, plays the crucial role in defense against intracellular bacteria. However, accumulating data indicate the importance of humoral immunity for the defense against a number of intracellular bacteria, including mycobacteria. We have investigated the role of secretory IgA, the main isotype found in mucosal tissues, in protection against mycobacterial infection, using polymeric IgR (pIgR)-deficient mice. Characterization of the humoral response induced after intra-nasal immunizations with the mycobacterial antigen PstS-1 revealed a loss of antigen-specific IgA response in saliva from the knockout mice. IgA level in the bronchoalveolar lavage of knockout mice was similar to wild-type level, although the IgA antibodies must have reached the lumen by other means than pIgR-mediated transport. Infection with Mycobacterium bovis bacillus Calmette–Guérin (BCG) demonstrated that the immunized pIgR−/− mice were more susceptible to BCG infection than immunized wild-type mice, based on higher bacterial loads in the lungs. This was accompanied by a reduced production of both IFN-γ and tumor necrosis factor-alpha (TNF-α) in the lungs. Additionally, the pIgR−/− mice displayed reduced natural resistance to mycobacterial infection proved by significantly higher bacterial growth in their lungs compared with wild-type mice after infection with virulent Mycobacterium tuberculosis. The knockout mice appeared to have a delayed mycobacteria-induced immune response with reduced expression of protective mediators, such as IFN-γ, TNF-α, inducible nitric oxide synthase and regulated upon activation normal T cell sequence, during early infection. Collectively, our results show that actively secreted IgA plays a role in protection against mycobacterial infections in the respiratory tract, by blocking entrance of bacilli into the lungs, in addition to modulation of the mycobacteria-induced pro-inflammatory response.
Ämnesord
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- mucosal immunity
- mycobacteria
- pIgR
- secretory IgA
- Immunology
- Immunologi
- Cell and molecular biology
- Cell- och molekylärbiologi
- Immunology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Tjärnlund, Anna
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Rodríguez, Arian ...
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Cardona, P J
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Guirado, E
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Ivanyi, J
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Singh, M
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visa fler...
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Marsh, P.D.
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Williams, A
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Troye-Blomberg, ...
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Fernandez, Carme ...
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visa färre...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Immunologi
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NATURVETENSKAP
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och Biokemi och mole ...
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Stockholms universitet