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Parallel synthesis ...
Parallel synthesis of an indole-based library via an iterativeMannich reaction sequence
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- Lindquist, Charlotta (författare)
- Organisk kemi, Avdelningen för kemi, KTH,Peter Somfai
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Ersoy, Oguz (författare)
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- Somfai, Peter (författare)
- KTH,Organisk kemi
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(creator_code:org_t)
- Elsevier Ltd. 2006
- 2006
- Engelska.
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Ingår i: Tetrahedron. - : Elsevier Ltd.. - 0040-4020 .- 1464-5416. ; 62:14, s. 3439-3445
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- A library of 1,3-disubstituted indoles has been prepared via an iterative Mannich reaction sequence. The first Mannich reaction with secondary amines and formaldehyde preferentially yields 3-aminomethyl indoles, while the second Mannich reaction introduces an additional aminomethyl group at the N1-position of the indole ring. A library of 25 substituted indoles has thus been prepared in moderate to good yields with purity.
Ämnesord
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Nyckelord
- Library synthesis
- Mannich reaction
- Affinity ligands
- Organic synthesis
- Organisk syntes
- organisk kemi
- Organic Chemistry
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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