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Recruited vs. nonre...
Recruited vs. nonrecruited molecular signatures of brown, “brite,” and white adipose tissues
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- Waldén, Tomas B. (author)
- Stockholms universitet,Wenner-Grens institut,The Wenner-Gren Institute, The Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden
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- Hansen, Ida R. (author)
- Stockholms universitet,Wenner-Grens institut
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- Timmons, James A. (author)
- Stockholms universitet,Wenner-Grens institut,The Royal Veterinary College, United Kingdom
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- Cannon, Barbara (author)
- Stockholms universitet,Wenner-Grens institut,The Royal Veterinary College, United Kingdom
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- Nedergaard, Jan (author)
- Stockholms universitet,Wenner-Grens institut
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(creator_code:org_t)
- American Physiological Society, 2012
- 2012
- English.
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In: American Journal of Physiology. Endocrinology and Metabolism. - : American Physiological Society. - 0193-1849 .- 1522-1555. ; 302:1, s. E19-E31
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Mainly from cell culture studies, a series of genes have been identified that have been suggested to be characteristic of different types of adipocytes. Here we have examined gene expression patterns in nine defined adipose depots: interscapular BAT, cervical BAT, axillary BAT, mediastinic BAT, cardiac WAT, inguinal WAT, retroperitoneal WAT, mesenteric WAT and epididymal WAT. We found that each depot displayed a distinct gene expression fingerprint, but that three major types of depots were identifiable: the brown, the brite and the white. Although differences in gene expression pattern were generally quantitative, some gene markers showed, even in-vivo, remarkable depot specificities: Zic1 for the classical brown adipose tissue depots, Hoxc9 for the brite depots, Hoxc8 for the brite and white in contrast to the brown, and Tcf21 for the white depots. The significance of these gene expression patterns both for understanding the developmental background of the depots and as possible master regulators is discussed.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Keyword
- uncoupling protein 1
- pr domain containing 16
- sirtuins
- short stature homeobox
- carbonic anhydrase 3
- Physiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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