Quantifying tumour hypoxia by PET imaging: a theoretical analysis

Quantifying tumour hypoxia by PET imaging : a theoretical analysis

Toma-Dasu, Iuliana (author): Karolinska Institutet,Stockholms universitet,Medicinsk strålningsfysik (tills m KI),Stockholm University and Karolinska Institutet

Daşu, Alexandru (author): Umeå universitet,Radiofysik,Norrlands University Hospital

Liss, P (author)

Hansell, P (author)

Bruley, DF (author)

Harrison, DK (author)

(creator_code:org_t)

Boston, MA : Springer US, 2009
2009
English.
In: Advances in Experimental Medicine and Biology. - Boston, MA : Springer US. - 0065-2598 .- 2214-8019. ; 645, s. 267-272

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; https://urn.kb.se/re...; https://urn.kb.se/re...; http://kipublication...; show less...

Abstract Subject headings

Information on tumour oxygenation could be obtained from various imaging methods, but the success of incorporating it into treatment planning depends on the accuracy of quantifying it. This study presents a theoretical analysis of the efficiency of measuring tumour hypoxia by PET imaging. Tissue oxygenations were calculated for ranges of biologically relevant physiological parameters and were then used to simulate PET images for markers with different uptake characteristics. The resulting images were used to calculate dose distributions that could lead to predefined tumour control levels. The results have shown that quantification of tumour hypoxia with PET may lead to different values according to the tracer used and the tumour site investigated. This would in turn be reflected into the dose distributions recommended by the optimisation algorithms. However, irrespective of marker-specific differences, focusing the radiation dose to the hypoxic areas appears to reduce the average tumour dose needed to achieve a certain control level.

By the author/editor: Toma-Dasu, Iulia ...; Daşu, Alexandru; Brahme, Anders; Liss, P; Hansell, P; Bruley, DF; show more...; Harrison, DK; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

By the university: Stockholm University; Umeå University; Linköping University; Karolinska Institutet

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