SwePub
Sök i LIBRIS databas

  Utökad sökning

id:"swepub:oai:DiVA.org:su-86285"
 

Sökning: id:"swepub:oai:DiVA.org:su-86285" > Haematological para...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004134naa a2200493 4500
001oai:DiVA.org:su-86285
003SwePub
008130111s2012 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-862852 URI
0247 a https://doi.org/10.1186/1756-0500-5-762 DOI
040 a (SwePub)su
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Sanou, Guillaume S4 aut
2451 0a Haematological parameters, natural regulatory CD4 + CD25 + FOXP3+ T cells and γδ T cells among two sympatric ethnic groups having different susceptibility to malaria in Burkina Faso.
264 c 2012-01-27
264 1b Springer Science and Business Media LLC,c 2012
338 a print2 rdacarrier
520 a BACKGROUND: Fulani ethnic group individuals are less susceptible than sympatric Mossi ethnic group, in term of malaria infection severity, and differ in antibody production against malaria antigens. The differences in susceptibility to malaria between Fulani and Mossi ethnic groups are thought to be regulated by different genetic backgrounds and offer the opportunity to compare haematological parameters, Tregs and γδT cell profiles in seasonal and stable malaria transmission settings in Burkina Faso. The study was conducted at two different time points i.e. during the high and low malaria transmission period.RESULTS: Two cross-sectional surveys were undertaken in adults above 20 years belonging either to the Fulani or the Mossi ethnic groups 1) at the peak of the malaria transmission season and 2) during the middle of the low malaria transmission season. Full blood counts, proportions of Tregs and γδ T cells were measured at both time-points.As previously shown the Fulani and Mossi ethnic groups showed a consistent difference in P. falciparum infection rates and parasite load. Differential white blood cell counts showed that the absolute lymphocyte counts were higher in the Mossi than in the Fulani ethnic group at both time points. While the proportion of CD4+CD25high was higher in the Fulani ethnic group at the peak of malaria transmission season (p = 0.03), no clear pattern emerged for T regulatory cells expressing FoxP3+ and CD127low. However CD3+γδ+ subpopulations were found to be higher in the Fulani compared to the Mossi ethnic group, and this difference was statistically significant at both time-points (p = 0.004 at low transmission season and p = 0.04 at peak of transmission).CONCLUSION: Our findings on regulatory T cell phenotypes suggest an interesting role for immune regulatory mechanisms in response to malaria. The study also suggests that TCRγδ + cells might contribute to the protection against malaria in the Fulani ethnic group involving their reported parasite inhibitory activities.
650 7a NATURVETENSKAPx Biologix Immunologi0 (SwePub)106052 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Immunology0 (SwePub)106052 hsv//eng
7001 a Tiendrebeogo, Régis W4 aut
7001 a Ouédraogo, André L4 aut
7001 a Diarra, Amidou4 aut
7001 a Ouédraogo, Alphonse4 aut
7001 a Yaro, Jean-Baptiste4 aut
7001 a Ouédraogo, Espérance4 aut
7001 a Verra, Federica4 aut
7001 a Behr, Charlotte4 aut
7001 a Troye-Blomberg, Maritau Stockholms universitet,Wenner-Grens institut4 aut0 (Swepub:su)marita
7001 a Modiano, David4 aut
7001 a Dolo, Amagana4 aut
7001 a Torcia, Maria G4 aut
7001 a Traoré, Yves4 aut
7001 a Sirima, Sodiomon B4 aut
7001 a Nébié, Issa4 aut
7102 a Stockholms universitetb Wenner-Grens institut4 org
7730 t BMC Research Notesd : Springer Science and Business Media LLCg 5, s. 76-(12 pp)q 5<76-(12 pp)x 1756-0500
8564 u https://doi.org/10.1186/1756-0500-5-76y Fulltext
8564 u https://bmcresnotes.biomedcentral.com/track/pdf/10.1186/1756-0500-5-76
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-86285
8564 8u https://doi.org/10.1186/1756-0500-5-76

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy