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Human metapneumovir...
Human metapneumovirus-associated severe acute respiratory illness hospitalisation in HIV-infected and HIV-uninfected South African children and adults
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Groome, Michelle J. (författare)
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Moyes, Jocelyn (författare)
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Cohen, Cheryl (författare)
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Walaza, Sibongile (författare)
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Tempia, Stefano (författare)
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Pretorius, Marthi (författare)
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Hellferscee, Orienka (författare)
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Chhagan, Meera (författare)
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Haffejee, Sumayya (författare)
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Dawood, Halima (författare)
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- Kahn, Kathleen (författare)
- Umeå universitet,Epidemiologi och global hälsa
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Variava, Ebrahim (författare)
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Cohen, Adam L. (författare)
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von Gottberg, Anne (författare)
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Wolter, Nicole (författare)
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Venter, Marietjie (författare)
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Madhi, Shabir A. (författare)
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(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- Engelska.
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Ingår i: Journal of Clinical Virology. - : Elsevier BV. - 1386-6532 .- 1873-5967. ; 69, s. 125-132
- Relaterad länk:
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https://repository.u...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background: Data on human metapneumovirus (HMPV)-associated severe acute respiratory illness (SARI) are limited in settings with high human immunodeficiency virus (HIV) infection prevalence. Objectives: To describe clinical characteristics and seasonality (all sites), and incidence (Soweto only) of HMPV-associated SARI among children and adults. Study design: Active, prospective, hospital-based, sentinel surveillance for patients hospitalised with SARI was conducted at four sites in South Africa from February 2009-December 2013. Upper respiratory tract samples were tested by multiplex real-time polymerase chain reaction assays for HMPV and other respiratory viruses. Incidence of hospitalisation, stratified by age and HIV-infection status, was calculated for one hospital with population denominators. Results: HMPV was identified in 4.1% of patients enrolled, including 5.6% (593/10503) in children and 1.7% in adults (>= 18 years; 119/6934). The majority of adults (84.0%) had an underlying medical condition, including HIV infection in 87/110 (79.1%). HMPV detection occurred perennially with periods of increased detection, which varied from year to year. The incidence of HMPV-associated hospitalisation in Soweto was highest in infants (653.3 per 100,000 person years; 95% confidence interval (CI) 602.2-707.6). The incidence was higher in HIV-infected persons compared to HIV-uninfected persons in age-groups 5-17 years (RR 6.0; 1.1-20.4), 18-44 years (RR 67.6; 38.0-132.6) and 45-64 years (RR 5.3; 3.4-8.3), while not differing in other age-groups. Conclusions: The burden of HMPV-associated SARI hospitalisation among adults occurred predominantly in HIV-infected persons. Among children, infants were at highest risk, with similar burden of hospitalisation in HIV-infected and HIV-uninfected children.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Human metapneumovirus
- HIV
- Lower respiratory tract infection
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- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Groome, Michelle ...
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Moyes, Jocelyn
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Cohen, Cheryl
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Walaza, Sibongil ...
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Tempia, Stefano
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Pretorius, Marth ...
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visa fler...
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Hellferscee, Ori ...
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Chhagan, Meera
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Haffejee, Sumayy ...
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Dawood, Halima
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Kahn, Kathleen
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Variava, Ebrahim
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Cohen, Adam L.
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von Gottberg, An ...
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Wolter, Nicole
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Venter, Marietji ...
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Madhi, Shabir A.
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visa färre...
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Umeå universitet