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Alterations in fact...
Alterations in factors involved in differentiation and barrier function in the epithelium in oral and genital lichen planus
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- Danielsson, Karin (author)
- Umeå universitet,Institutionen för odontologi,OLP GRUPPEN
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- Ebrahimi, Majid, 1963- (author)
- Umeå universitet,Institutionen för odontologi,OLP gruppen
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- Nylander, Elisabet (author)
- Umeå universitet,Dermatologi och venereologi,OLP gruppen
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- Wahlin, Ylva Britt (author)
- Umeå universitet,Institutionen för odontologi,OLP gruppen
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- Nylander, Karin (author)
- Umeå universitet,Patologi
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(creator_code:org_t)
- Medical Journals Sweden AB, 2017
- 2017
- English.
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In: Acta Dermato-Venereologica. - : Medical Journals Sweden AB. - 0001-5555 .- 1651-2057. ; 97:2, s. 214-218
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Abstract
Subject headings
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- Lichen planus is a chronic recurrent inflammatory disease affecting both skin and mucosa, mainly in oral and/or genital regions. Keratinocytes go through a well-regulated process of proliferation and differentiation, alterations in which may result in defects in the protective epithelial barrier. Long-term barrier impairment might lead to chronic inflammation. In order to broaden our understanding of the differentiation process in mucosal lichen planus, we mapped the expression of 4 factors known to be involved in differentiation. Biopsies were collected from oral and genital lichen planus lesions and normal controls. Altered expression of all 4 factors in epithelium from lichen planus lesions was found, clearly indicating disturbed epithelial differentiation in lichen planus lesions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Keyword
- lichen planus
- differentiation
- epithelial barrier
- medicinsk cellbiologi
- Medical Cell Biology
- Pathology
- patologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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