Tickborne relapsing fever diagnosis obscured by malaria, Togo.

Nordstrand, Annika (author)

Bunikis, Ignas (author): Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Bergström

Larsson, Christer (author): Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Bergström

Tsogbe, Kodjo (author)

Schwan, Tom G (author)

Nilsson, Mikael (author)

Bergström, Sven (author): Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Bergström

(creator_code:org_t)

2007
2007
English.
In: Emerging Infectious Diseases. - 1080-6040 .- 1080-6059. ; 13:1, s. 117-123

Related links:: http://www.ncbi.nlm....; show more...; https://urn.kb.se/re...; show less...

Abstract Subject headings

Given the prevalence of relapsing fever (RF) in Senegal, this disease may cause illness and death in other areas of West Africa. We performed a cross-sectional, clinic-based study to investigate the presence of RF in Togo during 2002-2004. Blood samples from patients with fever were examined for RF spirochetes by microscopy, PCR, and DNA sequencing of amplicons and for antibodies to the glycerophosphodiester phosphodiesterase antigen. Although no spirochetes were seen in blood smears, approximately 10% of the patients were positive by PCR and approximately 13% were seropositive for spirochetes. DNA sequencing demonstrated that Borrelia crocidurae and B. duttonii were present. Most patients were treated for malaria whether or not plasmodia were observed. Thus, many RF patients originally had a misdiagnosis of malaria, which resulted in ineffective treatment. The inability of microscopic analysis to detect spirochetes compared with PCR demonstrates the need for tests with greater sensitivity.

By the author/editor: Nordstrand, Anni ...; Bunikis, Ignas; Larsson, Christe ...; Tsogbe, Kodjo; Schwan, Tom G; Nilsson, Mikael; show more...; Bergström, Sven; show less...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.