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An updated evolutionary classification of CRISPR-Cas systems
- Makarova, Kira S (author)
- Wolf, Yuri I (author)
- Alkhnbashi, Omer S (author)
- show more...
- Costa, Fabrizio (author)
- Shah, Shiraz A (author)
- Saunders, Sita J (author)
- Barrangou, Rodolphe (author)
- Brouns, Stan J J (author)
- Haft, Daniel H (author)
- Horvath, Philippe (author)
- Moineau, Sylvain (author)
- Mojica, Francisco J M (author)
- Terns, Rebecca M (author)
- Terns, Michael P (author)
- White, Malcolm F (author)
- Yakunin, Alexander F (author)
- Garrett, Roger A (author)
- van der Oost, John (author)
- Backofen, Rolf (author)
- Koonin, Eugene V (author)
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- (creator_code:org_t)
- 2015-09-28
- 2015
- English.
- In: Nature Reviews Microbiology. - : Springer Science and Business Media LLC. - 1740-1526 .- 1740-1534. ; 13:11, s. 722-736
- Journal article (peer-reviewed)
Abstract
Subject headings
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- The evolution of CRISPR-cas loci, which encode adaptive immune systems in archaea and bacteria, involves rapid changes, in particular numerous rearrangements of the locus architecture and horizontal transfer of complete loci or individual modules. These dynamics complicate straightforward phylogenetic classification, but here we present an approach combining the analysis of signature protein families and features of the architecture of cas loci that unambiguously partitions most CRISPR-cas loci into distinct classes, types and subtypes. The new classification retains the overall structure of the previous version but is expanded to now encompass two classes, five types and 16 subtypes. The relative stability of the classification suggests that the most prevalent variants of CRISPR-Cas systems are already known. However, the existence of rare, currently unclassifiable variants implies that additional types and subtypes remain to be characterized.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- mikrobiologi
- Microbiology
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- ref (subject category)
- art (subject category)
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- Makarova, Kira S
- Wolf, Yuri I
- Alkhnbashi, Omer ...
- Costa, Fabrizio
- Shah, Shiraz A
- Saunders, Sita J
- show more...
- Barrangou, Rodol ...
- Brouns, Stan J J
- Charpentier, Emm ...
- Haft, Daniel H
- Horvath, Philipp ...
- Moineau, Sylvain
- Mojica, Francisc ...
- Terns, Rebecca M
- Terns, Michael P
- White, Malcolm F
- Yakunin, Alexand ...
- Garrett, Roger A
- van der Oost, Jo ...
- Backofen, Rolf
- Koonin, Eugene V
- show less...
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- NATURAL SCIENCES
- and Biological Scien ...
- and Genetics
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- NATURAL SCIENCES
- and Biological Scien ...
- and Microbiology
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