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A unique role of monocyte chemoattractant protein 1 among chemokines in adipose tissue of obese subjects

Dahlman, Ingrid (author)
Karolinska Institutet
Kaaman, Maria (author)
Olsson, Tommy (author)
Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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Tan, Garry D (author)
Bickerton, Alex S T (author)
Wåhlén, Kerstin (author)
Karolinska Institutet
Andersson, Jonas (author)
Department of Medicine, Umeå University Hospital, Umeå, Sweden
Arvidsson Nordström, Elisabet (author)
Karolinska Institutet
Blomqvist, Lennart (author)
Sjögren, Annelie (author)
Forsgren, Margaretha (author)
Attersand, Anneli (author)
Arner, Peter (author)
Karolinska Institutet
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 (creator_code:org_t)
Endocrine Society, 2005
2005
English.
In: Journal of Clinical Endocrinology and Metabolism. - : Endocrine Society. - 0021-972X .- 1945-7197. ; 90:10, s. 5834-5840
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Context: Low-grade inflammation in adipose tissue may contribute to insulin resistance in obesity. However, the roles of individual inflammatory mediators in adipose tissue are poorly understood. Objectives: The objective of this study was to determine which inflammation markers are most overexpressed at the gene level in adipose tissue in human obesity and how this relates to corresponding protein secretion. Design: We examined gene expression profiles in 17 lean and 20 obese subjects. The secretory pattern of relevant corresponding proteins was examined in human sc adipose tissue or isolated fat cells in vitro and in vivo in several obese or lean cohorts. Results: In ranking gene expression, defined pathways associated with obesity and immune and defense responses scored high. Among seven markedly overexpressed chemokines, only monocyte chemoattractant protein 1 (MCP1) was released from adipose tissue and isolated fat cells in vitro. In obesity, the secretion and expression of MCP1 in adipose tissue pieces were more than 6- and 2-fold increased, respectively, but there was no change in circulating MCP1 levels. There was no net release of MCP1, but there was a net release of leptin, in vivo from adipose tissue into the circulation. Conclusions: Obesity is associated with the increased expression of several chemokine genes in adipose tissue. However, only MCP1 is secreted into the extracellular space, where it primarily acts as a local factor, because little or no spillover into the circulation occurs. MCP1 influences the function of adipocytes, is a recruitment factor for macrophages, and may be a crucial link among chemokines between adipose tissue inflammation and insulin resistance.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Keyword

Adipose Tissue/*physiopathology
Adult
Body Mass Index
Chemokine CCL2/biosynthesis/*physiology
Chemokines/biosynthesis/*physiology
Female
Homeostasis/physiology
Humans
Immunity/physiology
Inflammation Mediators/physiology
Insulin Resistance
Male
Obesity/*physiopathology
Oligonucleotide Array Sequence Analysis
Proteins/metabolism
Reverse Transcriptase Polymerase Chain Reaction

Publication and Content Type

ref (subject category)
art (subject category)

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