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Sökning: id:"swepub:oai:DiVA.org:umu-138230" > Pre-diagnostic copp...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005316naa a2200829 4500
001oai:DiVA.org:umu-138230
003SwePub
008170818s2017 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:136252741
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1382302 URI
0247 a https://doi.org/10.1093/carcin/bgx0512 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1362527412 URI
040 a (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Stepien, Magdalena4 aut
2451 0a Pre-diagnostic copper and zinc biomarkers and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort
264 c 2017-06-01
264 1b OXFORD UNIV PRESS,c 2017
338 a print2 rdacarrier
520 a Adequate intake of copper and zinc, two essential micronutrients, are important for antioxidant functions. Their imbalance may have implications for development of diseases like colorectal cancer (CRC), where oxidative stress is thought to be etiologically involved. As evidence from prospective epidemiologic studies is lacking, we conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to investigate the association between circulating levels of copper and zinc, and their calculated ratio, with risk of CRC development. Copper and zinc levels were measured by reflection X-ray fluorescence spectrometer in 966 cases and 966 matched controls. Multivariable adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated using conditional logistic regression and are presented for the fifth versus first quintile. Higher circulating concentration of copper was associated with a raised CRC risk (OR = 1.50; 95% CI: 1.06, 2.13; P-trend = 0.02) whereas an inverse association with cancer risk was observed for higher zinc levels (OR = 0.65; 95% CI: 0.43, 0.97; P-trend = 0.07). Consequently, the ratio of copper/zinc was positively associated with CRC (OR = 1.70; 95% CI: 1.20, 2.40; P-trend = 0.0005). In subgroup analyses by follow-up time, the associations remained statistically significant only in those diagnosed within 2 years of blood collection. In conclusion, these data suggest that copper or copper levels in relation to zinc (copper to zinc ratio) become imbalanced in the process of CRC development. Mechanistic studies into the underlying mechanisms of regulation and action are required to further examine a possible role for higher copper and copper/ zinc ratio levels in CRC development and progression.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
7001 a Jenab, Mazda4 aut
7001 a Freisling, Heinz4 aut
7001 a Becker, Niels-Peter4 aut
7001 a Czuban, Magdalena4 aut
7001 a Tjonneland, Anne4 aut
7001 a Olsen, Anja4 aut
7001 a Overvad, Kim4 aut
7001 a Boutron-Ruault, Marie-Christine4 aut
7001 a Mancini, Francesca Romana4 aut
7001 a Savoye, Isabelle4 aut
7001 a Katzke, Verena4 aut
7001 a Kuehn, Tilman4 aut
7001 a Boeing, Heiner4 aut
7001 a Iqbal, Khalid4 aut
7001 a Trichopoulou, Antonia4 aut
7001 a Bamia, Christina4 aut
7001 a Orfanos, Philippos4 aut
7001 a Palli, Domenico4 aut
7001 a Sieri, Sabina4 aut
7001 a Tumino, Rosario4 aut
7001 a Naccarati, Alessio4 aut
7001 a Panico, Salvatore4 aut
7001 a Bueno-de-Mesquita, H. B. (as. )4 aut
7001 a Peeters, Petra H.4 aut
7001 a Weiderpass, Elisabeteu Karolinska Institutet4 aut
7001 a Merino, Susana4 aut
7001 a Jakszyn, Paula4 aut
7001 a Sanchez, Maria-Jose4 aut
7001 a Dorronsoro, Miren4 aut
7001 a Huerta, Jose Maria4 aut
7001 a Barricarte, Aurelio4 aut
7001 a Bodén, Stinau Umeå universitet,Onkologi4 aut0 (Swepub:umu)stabon98
7001 a van Guelpen, Behanyu Umeå universitet,Onkologi4 aut0 (Swepub:umu)beyvan99
7001 a Wareham, Nick4 aut
7001 a Khaw, Kay-Tee4 aut
7001 a Bradbury, Kathryn E.4 aut
7001 a Cross, Amanda J.4 aut
7001 a Schomburg, Lutz4 aut
7001 a Hughes, David J.4 aut
7102 a Karolinska Institutetb Onkologi4 org
7730 t Carcinogenesisd : OXFORD UNIV PRESSg 38:7, s. 699-707q 38:7<699-707x 0143-3334x 1460-2180
8564 u https://academic.oup.com/carcin/article-pdf/38/7/699/19287292/bgx051.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-138230
8564 8u https://doi.org/10.1093/carcin/bgx051
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:136252741

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