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Parasympathetic dys...
Parasympathetic dysfunction in hypertrophic cardiomyopathy assessed by heart rate variability: comparison between short-term and 24-h measurements
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- Mörner, Stellan (författare)
- Umeå universitet,Medicin
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- Wiklund, Urban (författare)
- Umeå universitet,Institutionen för strålningsvetenskaper
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Rask, Peter (författare)
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- Olofsson, Bert-Ove (författare)
- Umeå universitet,Medicin
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- Kazzam, Elsadig (författare)
- Umeå universitet,Medicin
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- Waldenström, Anders (författare)
- Umeå universitet,Medicin
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(creator_code:org_t)
- 2005
- 2005
- Engelska.
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Ingår i: Clinical Physiology and Functional Imaging. - 1475-0961 .- 1475-097X. ; 25:2, s. 90-99
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- In this study, we evaluate cardiac autonomic function in hypertrophic cardiomyopathy (HCM) by assessing heart rate variability (HRV), comparing a short-term laboratory method with an ambulatory (24-h) method, in patients with and without beta-blockade. Reduced HRV is a risk factor for adverse events in some cardiac diseases, but is not a proven risk indicator in HCM. Analysis of HRV has been based on either short- or long-term electrocardiographic recordings and previous studies in HCM have shown conflicting results. There is no consensus on which method to prefer, and we evaluate, for the first time, both short- and long-term analyses in patients with HCM. Long- and short-term HRV analyses were performed in 43 patients with HCM. They were divided in two groups, 22 patients on beta-blockade and 21 non-treated patients. As controls, 121 healthy subjects were used. Young patients without beta-blockade showed a reduction in HRV parameters reflecting parasympathetic function, both in the short- and long-term registrations, which was attenuated by beta-blockade. Parasympathetic autonomic regulation was found to be impaired in young patients with HCM. This may be of clinical relevance as abnormal autonomic function might be a substrate for malignant dysrhythmias. The impairment was attenuated by beta-blockade, which might indicate a clinically useful effect. We also show that short- and long-term methods yield similar results, suggesting that a short-term registration might be sufficient to assess HRV in patients with HCM.
Nyckelord
- Autonomic nervous system
- cross-sectional study
- heart rate variability
- hypertrophic cardiomyopathy
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- vet (ämneskategori)
- art (ämneskategori)
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