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Sökning: id:"swepub:oai:DiVA.org:umu-141830" > Difference in Clini...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004504naa a2200529 4500
001oai:DiVA.org:umu-141830
003SwePub
008171124s2017 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1418302 URI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a vet2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Ramirez, Jorge4 aut
2451 0a Difference in Clinical Presentation between Female and Male Patients with Primary Sjogren's Syndrome at Diagnosis and in Long-Term Follow-up
264 1b Wiley-Blackwell,c 2017
338 a print2 rdacarrier
500 a Supplement: 10Meeting Abstract: 1479
520 a Background/Purpose: Despite men being less prone to develop autoimmune diseases, male sex has been associated with a more severe disease course in several systemic autoimmune diseases. In the present study, we aimed to identify differences in clinical presentation between the sexes at the time of diagnosis and during long-term follow-up of primary Sjögren's syndrome (pSS), and to establish whether male sex is associated with a more severe form of pSS. Methods: Incident, treatment naïve patients (n=199, 186 females and 13 males) from Stockholm, Sweden were prospectively included during a 5-year period and examined for items of classification criteria for pSS as well as extraglandular manifestations (EGM). Serum was sampled at the time of diagnosis and anti-Ro52/SSA levels measured by ELISA. Replication of significant findings was confirmed in an independent cohort of incident pSS patients from Pisa, Italy (n=377, 368 females and 9 males), and meta-analysis performed. We further studied a cohort of 967 patients with prevalent pSS (899 females and 68 males) from Scandinavian clinical centers. The mean follow-up time (years) was 8.8 ± 7.6 for women and 8.5 ± 6.2 for men (ns). Clinical data including serological and hematological parameters, glandular, EGM and comorbidities were compared between men and women. Results: An increased frequency of EGM in men at diagnosis was observed and replicated (p=0.05, p=0.0003, and pmeta=0.002, respectively). This related to pulmonary involvement, vasculitis and lymphadenopathy being more common in men, for whom a lower age at diagnosis was observed in the exploratory cohort. Additionally, SSA positive male patients had significantly higher levels of anti-Ro52 levels than their female counterparts (p=0.02). After long-term follow-up, male patient serology was characterized by more frequent positivity for anti-SSA and anti-SSB (p=0.02), and ANA (p=0.02). Also, men with pSS were more frequently diagnosed with interstitial lung disease (p=0.008), lymphadenopathy (p=0.04) and lymphoma (p=0.007). Conversely, concomitant hypothyroidism was more common among female patients (p=0.009). Conclusion: Our analysis of two independent cohorts of incident pSS and a large cohort of prevalent pSS demonstrates significant differences between women and men with pSS. Notably, men present with more EGM, enhanced serological profile and a higher frequency of lymphoma development.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
653 a autoimmune diseases
653 a severity and sex bias
653 a Sjogren's syndrome
7001 a Kvarnstrom, Marika4 aut
7001 a Brauner, Susanna4 aut
7001 a Baldini, Chiara4 aut
7001 a Eriksson, Per4 aut
7001 a Mandl, Thomas4 aut
7001 a Norheim, Katrine Brække4 aut
7001 a Johnsen, Svein Joar4 aut
7001 a Hammenfors, Daniel S.4 aut
7001 a Jonsson, Malin V.4 aut
7001 a Skarstein, Kathrine4 aut
7001 a Brun, Johan G.4 aut
7001 a Rönnblom, Lars4 aut
7001 a Forsblad D'Elia, Helenau Umeå universitet,Reumatologi4 aut0 (Swepub:umu)hefo0034
7001 a Bucher, Sara Magnusson4 aut
7001 a Theander, Elke4 aut
7001 a Omdal, Roald4 aut
7001 a Jonsson, Roland4 aut
7001 a Nordmark, Gunnel4 aut
7001 a Wahren-Herlenius, Marie4 aut
7102 a Umeå universitetb Reumatologi4 org
7730 t Arthritis & Rheumatologyd : Wiley-Blackwellg 69q 69x 2326-5191x 2326-5205
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-141830

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