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Sökning: id:"swepub:oai:DiVA.org:umu-142380" > Cancer-associated f...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003874naa a2200505 4500
001oai:DiVA.org:umu-142380
003SwePub
008171129s2017 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1423802 URI
0247 a https://doi.org/10.1002/ijc.310112 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Eklöf, Vincy,d 1984-u Umeå universitet,Patologi4 aut0 (Swepub:umu)viyekf03
2451 0a Cancer-associated fecal microbial markers in colorectal cancer detection
264 c 2017-09-06
264 1b John Wiley & Sons,c 2017
338 a electronic2 rdacarrier
520 a Colorectal cancer (CRC) is the second most common cause of cancer death in the western world. An effective screening program leading to early detection of disease would severely reduce the mortality of CRC. Alterations in the gut microbiota have been linked to CRC, but the potential of microbial markers for use in CRC screening has been largely unstudied. We used a nested case-control study of 238 study subjects to explore the use of microbial markers for clbA+ bacteria harboring the pks pathogenicity island, afa-C+ diffusely adherent Escherichia coli harboring the afa-1 operon, and Fusobacterium nucleatum in stool as potential screening markers for CRC. We found that individual markers for clbA+ bacteria and F. nucleatum were more abundant in stool of patients with CRC, and could predict cancer with a relatively high specificity (81.5% and 76.9%, respectively) and with a sensitivity of 56.4% and 69.2%, respectively. In a combined test of clbA+ bacteria and F. nucleatum, CRC was detected with a specificity of 63.1% and a sensitivity of 84.6%. Our findings support a potential value of microbial factors in stool as putative noninvasive biomarkers for CRC detection. We propose that microbial markers may represent an important future screening strategy for CRC, selecting patients with a "high-risk" microbial pattern to other further diagnostic procedures such as colonoscopy.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a F. nucleatum
653 a clbA
653 a colorectal cancer
653 a gut microbiota
653 a screening
653 a stool
7001 a Löfgren-Burström, Annau Umeå universitet,Patologi4 aut0 (Swepub:umu)anlo0002
7001 a Zingmark, Carl,d 1975-u Umeå universitet,Patologi4 aut0 (Swepub:umu)cazi0001
7001 a Edin, Sofiau Umeå universitet,Patologi4 aut0 (Swepub:umu)soed0001
7001 a Larsson, Päru Umeå universitet,Patologi4 aut0 (Swepub:umu)pala0006
7001 a Karling, Pontusu Umeå universitet,Medicin4 aut0 (Swepub:umu)peakag84
7001 a Alexeyev, Olegu Umeå universitet,Patologi4 aut0 (Swepub:umu)olgalv83
7001 a Rutegård, Jörgen,d 1948-u Umeå universitet,Kirurgi4 aut0 (Swepub:umu)jaru0001
7001 a Wikberg, Maria Lu Umeå universitet,Patologi4 aut0 (Swepub:umu)mahe0061
7001 a Palmqvist, Richardu Umeå universitet,Patologi4 aut0 (Swepub:umu)ripa0001
7102 a Umeå universitetb Patologi4 org
7730 t International Journal of Cancerd : John Wiley & Sonsg 141:12, s. 2528-2536q 141:12<2528-2536x 0020-7136x 1097-0215
8564 u https://doi.org/10.1002/ijc.31011y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1161028/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.31011
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-142380
8564 8u https://doi.org/10.1002/ijc.31011

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