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Tumour-associated B...
Tumour-associated B cells in urothelial urinary bladder cancer
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- Zirakzadeh, A. Ali (author)
- Umeå universitet,Urologi och andrologi,Department of Medicine Solna, Unit of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden
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- Sherif, Amir (author)
- Umeå universitet,Urologi och andrologi
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- Rosenblatt, Robert (author)
- Umeå universitet,Urologi och andrologi
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Ahlén Bergman, Emma (author)
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- Winerdal, Max (author)
- Karolinska Institutet
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Yang, David (author)
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- Cederwall, Johanna (author)
- Umeå universitet,Urologi och andrologi
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Jakobsson, Vivianne (author)
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Hyllienmark, Martin (author)
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Winqvist, Ola (author)
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Marits, Per (author)
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(creator_code:org_t)
- 2019-12-10
- 2020
- English.
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In: Scandinavian Journal of Immunology. - : Wiley-Blackwell. - 0300-9475 .- 1365-3083. ; 91:2
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Tumour infiltrating B cells and CD38+ plasma cells have been correlated with survival in different malignancies but their role in urinary bladder cancer is unclear. IL-10 is a multifunctional cytokine with both anti-inflammatory and immunostimulatory properties, that can be released by regulatory B cells (Bregs). We have stained paraffin-embedded tumour sections from 31 patients with invasive urothelial urinary bladder cancer with respect to CD20+ B cells, CD38+ cells, IL-10-expressing cells, IgG, C1q and C3a and analysed the impact of these markers on survival. Interestingly, we observe tumour-associated CD20+ B cells forming follicle-like structures in tumours of some patients. We demonstrate that follicle-like structures, tumour-associated CD38+ cells, IL-10 produced by non-B cells, tumour infiltrating IgG and activation of the complement system, may associate to longer survival of urinary bladder cancer patients. IL-10 expression by tumour-associated Bregs may instead negatively affect prognosis. More research is needed to fully understand the role of B cells and IL-10 in urinary bladder cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- follicle-like structures
- tumour-associated B cells
- urinary bladder cancer
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Zirakzadeh, A. A ...
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Sherif, Amir
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Rosenblatt, Robe ...
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Ahlén Bergman, E ...
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Winerdal, Max
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Yang, David
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show more...
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Cederwall, Johan ...
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Jakobsson, Vivia ...
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Hyllienmark, Mar ...
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Winqvist, Ola
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Marits, Per
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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Scandinavian Jou ...
- By the university
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Umeå University
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Karolinska Institutet