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Characterizing pulsatility in distal cerebral arteries using 4D flow MRI
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- Vikner, Tomas (author)
- Umeå universitet,Radiofysik
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- Nyberg, Lars, 1966- (author)
- Umeå universitet,Diagnostisk radiologi,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Holmgren, Madelene (author)
- Umeå universitet,Radiofysik
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- (creator_code:org_t)
- Sage Publications, 2020
- 2020
- English.
- In: Journal of Cerebral Blood Flow and Metabolism. - : Sage Publications. - 0271-678X .- 1559-7016. ; 40:12, s. 2429-2440
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Recent reports have suggested that age-related arterial stiffening and excessive cerebral arterial pulsatility cause blood-brain barrier breakdown, brain atrophy and cognitive decline. This has spurred interest in developing non-invasive methods to measure pulsatility in distal vessels, closer to the cerebral microcirculation. Here, we report a method based on four-dimensional (4D) flow MRI to estimate a global composite flow waveform of distal cerebral arteries. The method is based on finding and sampling arterial waveforms from thousands of cross sections in numerous small vessels of the brain, originating from cerebral cortical arteries. We demonstrate agreement with internal and external reference methods and show the ability to capture significant increases in distal cerebral arterial pulsatility as a function of age. The proposed approach can be used to advance our understanding regarding excessive arterial pulsatility as a potential trigger of cognitive decline and dementia.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- 4D flow MRI
- cerebral hemodynamics
- arterial pulsatility
- cerebral cortical arteries
- aging
Publication and Content Type
- ref (subject category)
- art (subject category)
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