id:"swepub:oai:DiVA.org:umu-173463"
Search: id:"swepub:oai:DiVA.org:umu-173463" > Sleep apnea in men ...
- 1 of 1
- Previous record
- Next record
- To hitlist
Sleep apnea in men is associated with altered lipid metabolism, glucose tolerance, insulin sensitivity, and body fat percentage
-
- Kamble, Prasad G. (author)
- Uppsala universitet,Klinisk diabetologi och metabolism
-
- Theorell-Haglöw, Jenny (author)
- Uppsala universitet,Lung- allergi- och sömnforskning
-
- Wiklund, Urban (author)
- Umeå universitet,Radiofysik
- show more...
- Eriksson, Jan W (author)
- show less...
- (creator_code:org_t)
- 2020-06-19
- 2020
- English.
- In: Endocrine. - : Springer. - 1355-008X .- 1559-0100. ; 70, s. 48-57
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Purpose: Obstructive sleep apnea (OSA) is associated with obesity and risk for type 2 diabetes. In this community-based study, we thoroughly investigated fatty acid metabolism, incretin response, glucose tolerance, insulin secretion and insulin sensitivity, and autonomic nerve activity in men with or without OSA.Methods: Fifteen men without diabetes but with signs of severe OSA, defined as apnea–hypopnea index (AHI) >30, and 15 age- and BMI-matched men without OSA (AHI < 5) were recruited from a community-based cohort. Assessments included clinical and anthropometric measurements, a 2-h oral glucose tolerance test (OGTT), and autonomic nerve activity using heart rate variability (HRV).Results: Men with OSA had higher body fat % than BMI-matched men without OSA (p = 0.046) and it was associated with markers of insulin resistance. The area under the curve for nonesterified fatty acids (NEFA) during OGTT was higher in men with OSA (p = 0.021) and fasting NEFA levels were numerically higher (p = 0.097). The plasma glucose at fasting and during OGTT was higher in men with OSA (p < 0.001). Incretin response was similar between groups. Fasting and OGTT-derived indices indicated impaired insulin sensitivity in men with OSA. Compared with men without OSA, Matsuda index (p = 0.068) and Gutt index (p < 0.01) were lower in men with OSA. The HRV measures did not differ between groups.Conclusions: Our study suggests that fatty acid handling, glucose tolerance, and insulin sensitivity are impaired in men with severe OSA. This might partly be explained by the increased body fat percentage.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Obstructive sleep apnea
- Glucose metabolism
- Lipid metabolism
- Insulin secretion
Publication and Content Type
- ref (subject category)
- art (subject category)
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Kamble, Prasad G ...
- Theorell-Haglöw, ...
- Wiklund, Urban
- Franklin, Karl A ...
- Hammar, Ulf
- Lindberg, Eva
- show more...
- Eriksson, Jan W
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Endocrinology an ...
- Articles in the publication
- Endocrine
- By the university
- Umeå University
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
