id:"swepub:oai:DiVA.org:umu-186468"
Search: id:"swepub:oai:DiVA.org:umu-186468" > The burden of hand,...
- 1 of 1
- Previous record
- Next record
- To hitlist
The burden of hand, foot, and mouth disease among children under different vaccination scenarios in China: a dynamic modelling study
-
- Liu, Zhixi (author)
- School of Public Health, Fudan University, Shanghai, China
-
- Tian, Jie (author)
- School of Public Health, Fudan University, Shanghai, China
-
- Wang, Yue (author)
- School of Public Health, Fudan University, Shanghai, China
- show more...
- show less...
- (creator_code:org_t)
- 2021-07-05
- 2021
- English.
- In: BMC Infectious Diseases. - : Springer Science and Business Media LLC. - 1471-2334. ; 21:1
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- BACKGROUND: Hand, foot, and mouth disease (HFMD) is a common illness in young children. A monovalent vaccine has been developed in China protecting against enterovirus-71, bivalent vaccines preventing HFMD caused by two viruses are under development.OBJECTIVE: To predict and compare the incidence of HFMD under different vaccination scenarios in China.METHODS: We developed a compartmental model to capture enterovirus transmission and the natural history of HFMD in children aged 0-5, and calibrated to reported cases in the same age-group from 2015 to 2018. We compared the following vaccination scenarios: different combinations of monovalent and bivalent vaccine; a program of constant vaccination to that of pulse vaccination prior to seasonal outbreaks.RESULTS: We estimate 1,982,819, 2,258,846, 1,948,522 and 2,398,566 cases from 2015 to 2018. Increased coverage of monovalent vaccine from 0 to 80% is predicted to decrease the cases by 797,262 (49.1%). Use of bivalent vaccine at an 80% coverage level would decrease the cases by 828,560. Use of a 2.0× pulse vaccination for the bivalent vaccine in addition to 80% coverage would reduce cases by over one million. The estimated R0 for HFMD in 2015-2018 was 1.08, 1.10, 1.35 and 1.17.CONCLUSIONS: Our results point to the benefit of bivalent vaccine and using a pulse vaccination in specific months over routine vaccination. Other ways to control HFMD include isolation of patients in the early stage of dissemination, more frequent hand-washing and ventilation, and better treatment options for patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- Basic reproductive number
- Hand
- foot and mouth disease
- Pulse vaccination
- SEIR model
- Vaccine
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- BMC Infectious Diseases (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Liu, Zhixi
- Tian, Jie
- Wang, Yue
- Li, Yixuan
- Liu-Helmersson, ...
- Mishra, Sharmist ...
- show more...
- Wagner, Abram L.
- Lu, Yihan
- Wang, Weibing
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Infectious Medic ...
- Articles in the publication
- BMC Infectious D ...
- By the university
- Umeå University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
