SwePub
Sök i LIBRIS databas

  Extended search

id:"swepub:oai:DiVA.org:umu-187745"
 

Search: id:"swepub:oai:DiVA.org:umu-187745" > The Cerebrospinal F...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

The Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features

Griffiths, William J. (author)
Swansea University Medical School, ILS1 Building, Swansea, United Kingdom
Abdel-Khalik, Jonas (author)
Swansea University Medical School, ILS1 Building, Swansea, United Kingdom
Moore, Sarah F. (author)
Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
show more...
Wijeyekoon, Ruwani S. (author)
Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
Crick, Peter J. (author)
Swansea University Medical School, ILS1 Building, Swansea, United Kingdom
Yutuc, Eylan (author)
Swansea University Medical School, ILS1 Building, Swansea, United Kingdom
Farrell, Krista (author)
Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
Breen, David P. (author)
Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom; Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, United Kingdom; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom
Williams-Gray, Caroline H. (author)
Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
Theofilopoulos, Spyridon (author)
Swansea University Medical School, ILS1 Building, Swansea, United Kingdom
Arenas, Ernest (author)
Karolinska Institutet
Trupp, Miles (author)
Umeå universitet,Neurovetenskaper
Barker, Roger A. (author)
Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
Wang, Yuqin (author)
Swansea University Medical School, ILS1 Building, Swansea, United Kingdom
show less...
 (creator_code:org_t)
2021-08-30
2021
English.
In: Frontiers in Aging Neuroscience. - : Frontiers Media S.A.. - 1663-4365. ; 13
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Disordered cholesterol metabolism is linked to neurodegeneration. In this study we investigated the profile of cholesterol metabolites found in the cerebrospinal fluid (CSF) of Parkinson’s disease (PD) patients. When adjustments were made for confounding variables of age and sex, 7α,(25R)26-dihydroxycholesterol and a second oxysterol 7α,x,y-trihydroxycholest-4-en-3-one (7α,x,y-triHCO), whose exact structure is unknown, were found to be significantly elevated in PD CSF. The likely location of the additional hydroxy groups on the second oxysterol are on the sterol side-chain. We found that CSF 7α-hydroxycholesterol levels correlated positively with depression in PD patients, while two presumptively identified cholestenoic acids correlated negatively with depression.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Keyword

bile acid biosynthesis
dihydroxycholesterol
mass spectrometry
oxysterol
sterol

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view