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Altered Expression ...
Altered Expression of the Hedgehog Pathway Proteins BMP2, BMP4, SHH, and IHH Involved in Knee Cartilage Damage of Patients With Osteoarthritis and Kashin-Beck Disease
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- Deng, Huan (author)
- School of Public Health, Xi'an Jiaotong University, Health Science Center, Xi'an, China
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- Xiao, Xiang (author)
- School of Public Health, Xi'an Jiaotong University, Health Science Center, Xi'an, China
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- Chilufya, Mumba Mulutula (author)
- School of Public Health, Xi'an Jiaotong University, Health Science Center, Xi'an, China
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- Qiao, Lichun (author)
- School of Public Health, Xi'an Jiaotong University, Health Science Center, Xi'an, China
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- Lv, Yizhen (author)
- School of Public Health, Xi'an Jiaotong University, Health Science Center, Xi'an, China
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- Guo, Ziwei (author)
- School of Public Health, Xi'an Jiaotong University, Health Science Center, Xi'an, China
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- Lei, Jian (author)
- School of Public Health, Shanghai Medical College of Fudan University, Shanghai, China
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- Liu, Jiaxin (author)
- School of Public Health, Xi'an Jiaotong University, Health Science Center, Xi'an, China
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- Zhao, Yan (author)
- School of Public Health, Xi'an Jiaotong University, Health Science Center, Xi'an, China
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- Zhang, Jiaheng (author)
- School of Public Health, Xi'an Jiaotong University, Health Science Center, Xi'an, China
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- Wang, Wenyue (author)
- School of Public Health, Xi'an Jiaotong University, Health Science Center, Xi'an, China
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- Han, Jing (author)
- School of Public Health, Xi'an Jiaotong University, Health Science Center, Xi'an, China
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- Qu, Chengjuan, 1967- (author)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)
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(creator_code:org_t)
- 2022-03-21
- 2022
- English.
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In: Cartilage. - : Sage Publications. - 1947-6035 .- 1947-6043. ; 13:1
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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Abstract
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- OBJECTIVE: To investigate the expression of Hedgehog (HH) signaling pathway proteins in knee articular cartilage from Kashin-Beck disease (KBD) and osteoarthritis (OA) patients.METHODS: Knee articular cartilage samples were collected from normal (N), OA, and KBD adults (aged 38-60 years) and divided into 3 groups with 6 subjects in each group. The localization of the HH pathway proteins bone morphogenetic protein 2 (BMP2), bone morphogenetic protein 4 (BMP4), Sonic hedgehog (SHH), and Indian hedgehog (IHH) was observed with the microscope after immunohistochemical (IHC) staining. Positive staining cell rates of each proteins were compared.RESULTS: The strongest stainings of all proteins were observed in the middle zones of all 3 groups. The positive staining rates of BMP4 and IHH were significantly lower in the OA and KBD groups than those in the N group in all 3 zones. The positive staining rates of BMP2 and SHH tend to be lower in the OA and KBD groups than those in the N group in the deep zone, while higher in the OA and KBD groups than those in the N group in superficial and middle zones.CONCLUSIONS: Altered expression of the HH pathway proteins BMP2, BMP4, SHH, and IHH was found in OA and KBD articular cartilage. There seemed to be a compensatory effect between SHH and IHH in cartilage damage. Further studies on the pathogenesis of OA and KBD may be carried out from these aspects in the future.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- articular cartilage
- Hedgehog pathway
- immunohistochemistry
- Kashin-Beck disease
- osteoarthritis
Publication and Content Type
- ref (subject category)
- art (subject category)
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Cartilage
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- By the author/editor
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Deng, Huan
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Xiao, Xiang
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Chilufya, Mumba ...
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Qiao, Lichun
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Lv, Yizhen
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Guo, Ziwei
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Lei, Jian
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Liu, Jiaxin
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Zhao, Yan
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Zhang, Jiaheng
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Wang, Wenyue
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Han, Jing
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Qu, Chengjuan, 1 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Orthopaedics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Cartilage
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Umeå University