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Brain aging differs...
Brain aging differs with cognitive ability regardless of education
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- Walhovd, Kristine B. (author)
- Center for Lifespan Changes in Brain and Cognition, University of Oslo, Blindern, Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway
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- Nyberg, Lars, 1966- (author)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för strålningsvetenskaper,Center for Lifespan Changes in Brain and Cognition, University of Oslo, Blindern, Oslo, Norway
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- Lindenberger, Ulman (author)
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, London, United Kingdom
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- Amlien, Inge K. (author)
- Center for Lifespan Changes in Brain and Cognition, University of Oslo, Blindern, Oslo, Norway
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- Sørensen, Øystein (author)
- Center for Lifespan Changes in Brain and Cognition, University of Oslo, Blindern, Oslo, Norway
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- Wang, Yunpeng (author)
- Center for Lifespan Changes in Brain and Cognition, University of Oslo, Blindern, Oslo, Norway
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- Mowinckel, Athanasia M. (author)
- Center for Lifespan Changes in Brain and Cognition, University of Oslo, Blindern, Oslo, Norway
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- Kievit, Rogier A. (author)
- Cognitive Neuroscience Department, Donders Institute for Brain, Cognition and Behavior, The Netherlands, Radboud University Medical Center, Nijmegen, Netherlands
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- Ebmeier, Klaus P. (author)
- Department of Psychiatry, University of Oxford, Oxford, United Kingdom
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- Bartrés-Faz, David (author)
- Department of Medicine, Faculty of Medicine and Health Sciences & Institute of Neurosciences, Universitat de Barcelona, and Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
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- Kühn, Simone (author)
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Clinic and Policlinic for Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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- Boraxbekk, Carl-Johan, 1980- (author)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Diagnostisk radiologi,Danish Research Centre for Magnetic Resonance (DRCMR), Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark; Institute of Sports Medicine Copenhagen (ISMC) and Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark; Institute for Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark
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- Ghisletta, Paolo (author)
- Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland; UniDistance Suisse, Brig, Switzerland; Swiss National Centre of Competence in Research LIVES, University of Geneva, Geneva, Switzerland
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- Madsen, Kathrine Skak (author)
- Danish Research Centre for Magnetic Resonance (DRCMR), Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark; Radiography, Department of Technology, University College Copenhagen, Copenhagen, Denmark
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- Baaré, Willliam F. C. (author)
- Danish Research Centre for Magnetic Resonance (DRCMR), Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark
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- Zsoldos, Enikő (author)
- Department of Psychiatry, University of Oxford, Oxford, United Kingdom; Welcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom
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- Magnussen, Fredrik (author)
- Center for Lifespan Changes in Brain and Cognition, University of Oslo, Blindern, Oslo, Norway
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- Vidal-Piñeiro, Didac (author)
- Center for Lifespan Changes in Brain and Cognition, University of Oslo, Blindern, Oslo, Norway
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- Penninx, Brenda (author)
- Amsterdam Neuroscience, Department of Psychiatry, Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands
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- Fjell, Anders M. (author)
- Center for Lifespan Changes in Brain and Cognition, University of Oslo, Blindern, Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway
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(creator_code:org_t)
- 2022-08-16
- 2022
- English.
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In: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 12:1
- Related links:
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Abstract
Subject headings
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- Higher general cognitive ability (GCA) is associated with lower risk of neurodegenerative disorders, but neural mechanisms are unknown. GCA could be associated with more cortical tissue, from young age, i.e. brain reserve, or less cortical atrophy in adulthood, i.e. brain maintenance. Controlling for education, we investigated the relative association of GCA with reserve and maintenance of cortical volume, -area and -thickness through the adult lifespan, using multiple longitudinal cognitively healthy brain imaging cohorts (n = 3327, 7002 MRI scans, baseline age 20–88 years, followed-up for up to 11 years). There were widespread positive relationships between GCA and cortical characteristics (level-level associations). In select regions, higher baseline GCA was associated with less atrophy over time (level-change associations). Relationships remained when controlling for polygenic scores for both GCA and education. Our findings suggest that higher GCA is associated with cortical volumes by both brain reserve and -maintenance mechanisms through the adult lifespan.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Neurology
- neurologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Walhovd, Kristin ...
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Nyberg, Lars, 19 ...
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Lindenberger, Ul ...
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Amlien, Inge K.
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Sørensen, Øystei ...
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Wang, Yunpeng
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Mowinckel, Athan ...
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Kievit, Rogier A ...
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Ebmeier, Klaus P ...
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Bartrés-Faz, Dav ...
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Kühn, Simone
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Boraxbekk, Carl- ...
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Ghisletta, Paolo
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Madsen, Kathrine ...
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Baaré, Willliam ...
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Zsoldos, Enikő
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Magnussen, Fredr ...
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Vidal-Piñeiro, D ...
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Penninx, Brenda
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Fjell, Anders M.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Scientific Repor ...
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Umeå University