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Lumen apposing metal stents vs double pigtail plastic stents for the drainage of pancreatic walled-off necrosis

Valente, Roberto (author)
Umeå universitet,Kirurgi,Department of Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Surgical Oncology, Anschutz Medical Campus, University of Colorado, Denver, CO, USA,Karolinska Inst, Dept Surg, Stockholm, Sweden.;Univ Colorado, Div Surg Oncol, Anschutz Med Campus, Denver, CO USA.;Umeå Univ Hosp, Dept Surg, Umeå, Sweden.;Karolinska Inst, Stockholm, Sweden.
Zarantonello, Laura (author)
Uppsala universitet,Gastrointestinalkirurgi
Del Chiaro, Marco (author)
Department of Surgical Oncology, Anschutz Medical Campus, University of Colorado, Denver, CO, USA,Univ Colorado, Div Surg Oncol, Anschutz Med Campus, Denver, CO USA.
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Vujasinovic, Miroslav (author)
Karolinska Institutet,Karolinska Univ Hosp, Dept Upper Digest Dis, Stockholm, Sweden.
Baldaque Silva, Francisco (author)
Karolinska Institutet,Karolinska Univ Hosp, Dept Upper Digest Dis, Stockholm, Sweden.
Scandavini, Chiara M. (author)
Umeå universitet,Kirurgi,Umeå Univ Hosp, Dept Surg, Umeå, Sweden.
Rangelova, Elena (author)
Department of Surgery, Sahlgrenska Hospital, Gothenburg, Sweden,Sahlgrenska Hosp, Dept Surg, Gothenburg, Sweden.
Vespasiano, Francesca (author)
Department of Upper Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden,Karolinska Univ Hosp, Dept Upper Digest Dis, Stockholm, Sweden.
Anzillotti, Giuseppe (author)
Department of Upper Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden,Karolinska Univ Hosp, Dept Upper Digest Dis, Stockholm, Sweden.
Löhr, Johannes M. (author)
Karolinska Institutet,Karolinska Inst, Dept Surg, Stockholm, Sweden.;Uppsala Univ Hosp, Dept Surg, Uppsala, Sweden.
Arnelo, Urban (author)
Karolinska Institutet,Umeå universitet,Kirurgi,Department of Surgery, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Dept Surg, Stockholm, Sweden.;Umeå Univ Hosp, Dept Surg, Umeå, Sweden.
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 (creator_code:org_t)
Edizioni Minerva Medica, 2024
2024
English.
In: Minerva gastroenterology. - : Edizioni Minerva Medica. - 2724-5365. ; 70:1, s. 1-9
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • BACKGROUND: Few studies compared lumen-apposing metal stents (LAMS) and standard double pigtail plastic stents (PS) for the endoscopic drainage of pancreatic walled-off necrosis (WON). Albeit sometimes large, previously described cohorts display considerable heterogeneity and often pooled together data from several centers, involving multiple operators and techniques. Moreover, they often lack a control group for the comparison of outcomes.AIM: to compare clinical efficacy and safety of PS versus LAMS for the endoscopic drainage of infected WON.METHODS: Single-centre, 1:1 case-control study. We compared patients undergoing endoscopic drainages of infected WON through LAMS (cases) or PS (controls). The primary endpoint was the clinical efficacy (resolution of the WON/sepsis), the secondary endpoint was safety (procedure-related complications).RESULTS: Thirty patients were enrolled between 2011 and 2017. Cases and controls were homogeneous in terms of etiology and clinical characteristics. 93% of cases and 86.7% of controls were clinically successfully treated, with no significant differences in rates of post-operative infections, bleedings and stent migrations (respectively 13.3% vs 21.4%; p=0.65; 13.3% vs 0%; p=0.48; 13.3% vs 7.1%; p=1.00). No difference was shown regarding the need for additional percutaneous or surgical treatments (33.3% vs 13.3%; p=0.39). Cases, however, displayed a significantly prolonged mean hospital stay (90.2 days vs 18.5 days; p<0.01) and a higher mean number of endoscopic procedures per patient (4.8 vs 1.5; p<0.01).CONCLUSIONS: PS might be not inferior to LAMS for the treatment WONs. Further prospective RCT is needed to compare clinical efficacy and safety in the two groups.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kirurgi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Surgery (hsv//eng)

Keyword

Acute pancreatitis
Double pigtails plastic stents
LAMS
WON

Publication and Content Type

ref (subject category)
art (subject category)

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